Author(s): Coleman CI, Reinhart K, Kluger J, White CM
Objective: To determine the ability of statins to prevent the development of new-onset type 2 diabetes mellitus through a meta-analysis of randomized, controlled trials.
Research design and methods: A systematic literature search through November 6, 2007 was conducted to identify randomized, placebo-controlled trials of statins that reported data on the incidence of new-onset diabetes mellitus. Incidence of new-onset type 2 diabetes mellitus was treated as a dichotomous variable. Weighted averages were reported as relative risk (RR) with associated 95% confidence intervals (CI). A random-effects model was used.
Results: Five prospective, randomized controlled trials (n = 39,791) were identified. Upon meta-analysis, the use of a statin did not significantly alter a patient's risk of developing new-onset type 2 diabetes mellitus (relative risk, 1.03; 95% confidence interval 0.89-1.19). Subgroup and sensitivity analyses did not significantly change the results. There was statistical heterogeneity that stemmed from pravastatin's tendency towards a reduction in risk and the other statins showing an increase in risk. The funnel plot could not rule out publication bias.
Conclusions: Statins, as a class, do not demonstrate a statistically significant positive or negative impact on a patient's risk of developing new-onset type 2 diabetes mellitus.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/18384710
Author(s): Cholesterol Treatment Trialists’ (CTT) Collaboration, Baigent C, Blackwell L, Emberson J, Holland LE, et al.
Author(s): Freeman DJ, Norrie J, Sattar N, Neely RD, Cobbe SM, et al.
Author(s): Ridker PM, Danielson E, Fonseca FA, Genest J, Gotto AM Jr, et al.
Author(s): Baker WL, Talati R, White CM, Coleman CI
Author(s): Sattar N, Preiss D, Murray HM, Welsh P, Buckley BM, et al.
Author(s): Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, et al.
Author(s): DeFronzo RA, Tobin JD, Andres R
Author(s): Koshiyama H, Taniguchi A, Tanaka K, Kagimoto S, Fujioka Y, et al.
Author(s): Miyashita Y, Endo K, Saiki A, Ban N, Yamaguchi T, et al.
Author(s): Sakabe K, Fukuda N, Fukuda Y, Wakayama K, Nada T, et al.
Author(s): Inami N, Nomura S, Shouzu A, Omoto S, Kimura Y, et al.
Author(s): Nakata M, Nagasaka S, Kusaka I, Matsuoka H, Ishibashi S, et al.
Author(s): Yada T, Nakata M, Shiraishi T, Kakei M
Author(s): Ishihara Y, Ohmori K, Mizukawa M, Hasan AU, Noma T, et al.
Author(s): Yamazaki T, Kishimoto J, Ito C, Noda M, Odawara M, et al.