Author(s): Cuciureanu M, Caruntu ID, Paduraru O, Stoica B, Jerca L, et al.
Aim: This study investigates the effects of montelukast sodium (MK) (CysLTLT1 receptor antagonist) on CCl(4)induced hepatopathy on rat.
Material and methods: We worked on 4 groups of 10 Wistar male rats each. The groups received as follows: group I (control group) - saline, group II - MK 5mg/kg/day i.p. for 5 days, group III - MK 5mg/kg/day i.p., 1 day prior to and 4 days concomitantly with CCl(4) p.o., 0.3ml/Kg/day and group IV - CCl(4), p.o., 0.3ml/Kg/day for 4 days. One day after the last administration, samples of blood were taken and alanine aminotransferase (ALT), total bilirubin (TB), direct bilirubin (DB), malondialdehyde (MDA), catalase (CAT) as well as total antioxidant capacity (TAC) were determined. The histopathological exam was performed. We also determined superoxide dismutase (SOD), MDA, CAT and GSH in liver homogenate.
Results: Compared to group IV, group III exhibited statistically significant lower levels of ALT (318+/-15.75 versus 203.14+/-10.28 UI, p<0.0001), TB (3.16+/-0.30 versus 1.99+/-0.08mg/dl, p<0.0001), MDA in blood and in liver homogenate (4.98+/-1.71 versus 2.15+/-1.18nmol/ml, p=0.0004) and higher levels of SOD and CAT. Histopathologically, group IV presented important macro- and micro-vesicular hepatic steatosis and group III preserved lobular histoarchitecture and had less severe cellular lesions.
Conclusion: MK exhibits a partial hepatoprotective effect on rats treated with CCl(4).
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/19041730
Author(s): Shaw JE, Sicree RA, Zimmet PZ
Author(s): Wild S, Roglic G, Green A, Sicree R, King H
Author(s): Shi Y, Vanhoutte PM
Author(s): Elmarakby AA, Sullivan JC
Author(s): Tiganis T
Author(s): Pitocco D, Zaccardi F, Di Stasio E, Romitelli F, Santini SA, et al.
Author(s): Wei W, Liu Q, Tan Y, Liu L, Li X, et al.
Author(s): Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB
Author(s): Narayana K
Author(s): Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, et al.
Author(s): Beem KM, Richardson DC, Rajagopalan KV
Author(s): Horn A Jr, Parrilha GL, Melo KV, Fernandes C, Horner M, et al.
Author(s): Nassini R, Andrè E, Gazzieri D, De Siena G, Zanasi A, et al.
Author(s): Huang KC, Yang CC, Lee KT, Chien CT
Author(s): Hofer T, Marzetti E, Xu J, Seo AY, Gulec S, et al.
Author(s): Jin D, Ryu SH, Kim HW, Yang EJ, Lim SJ, et al.
Author(s): Shomar B
Author(s): Johansson LH, Borg LA
Author(s): Wheeler CR, Salzman JA, Elsayed NM, Omaye ST, Korte DW Jr
Author(s): Baker MA, Cerniglia GJ, ZamanA
Author(s): Armstrong D, Browne R
Author(s): Liu D
Author(s): Shirahata S, Kabayama S, Nakano M, Miura T, Kusumoto K, et al.
Author(s): Hanaoka K
Author(s): Lee MY, Kim YK, Ryoo KK, Lee YB, Park EJ
Author(s): Kim MJ, Jung KH, Uhm YK, Leem KH, Kim HK
Author(s): Jain SK, McVie R
Author(s): Testa R, Testa I, Manfrini S, Bonfigli AR, Piantanelli L, et al.
Author(s): Santos-Oliveira R, Purdy C, da Silva MP, dos Anjos Carneiro-Leão AM, Machado M, et al.
