The relationship between carnitine and ketone body levels in diabetic children

Author(s): Soltész G, Melegh B, Sándor A


Free carnitine was significantly (p less than 0.001) reduced both in the ketotic (29.7 +/- 3.4 nmol/ml) and in the ketoacidotic (24.6 +/- 1.4 nmol/ml) groups when compared to controls (50.0 +/- 2.4 nmol/ml). At the same time, acylcarnitine values in the ketotic (21.2 +/- 2.4 nmol/ml) and ketoacidotic (25.4 +/- 2.3 nmol/ml) groups were significantly above the control value (4.71 +/- 0.6 nmol/ml). There was no significant difference between the two ketotic groups in carnitine derivatives. The abnormal distribution of plasma free and acylcarnitines could be reversed by insulin treatment. There was an inverse correlation between ketone body levels and free carnitine in the ketotic (r = -0.71, p less than 0.02) and ketoacidotic group (r = -0.71, p less than 0.05). However, there was no correlation between ketone bodies and acylcarnitine and between free carnitine and acylcarnitines. We concluded that the increased acylation was only partly responsible for the reduction of free carnitine in diabetic ketosis.

Similar Articles

Triglyceride metabolism in pregnancy

Author(s): Ghio A, Bertolotto A, Resi V, Volpe L, Di Cianni G

Energy metabolism during human pregnancy

Author(s): Forsum E, Löf M

Clinical and biochemical features of fatty acid oxidation disorders

Author(s): Rinaldo P, Raymond K, al-Odaib A, Bennett MJ

Plasma carnitine levels of pregnant adolescents in labor

Author(s): Koumantakis E, Sifakis S, Koumantaki Y, Hassan E, Matalliotakis I, et al.

Pregnancy-related changes of carnitine and acylcarnitine concentrations of plasma and erythrocytes

Author(s): Schoderbeck M, Auer B, Legenstein E, Genger H, Sevelda P, et al.

Carnitine status and lactate increase in patients with type I juvenile diabetes

Author(s): Evangeliou A, Gourgiotis D, Karagianni C, Markouri M, Anogianaki N, et al.

The effect of the mode of delivery on the maternal-neonatal carnitine blood levels and antioxidant status

Author(s): Schulpis KH, Papakonstantinou ED, Vlachos GD, Vlachos DG, Antsaklis A, et al.

Current understanding of placental fatty acid transport

Author(s): Gil-Sánchez A, Koletzko B, Larqué E

Maternal lipid metabolism and placental lipid transfer

Author(s): Herrera E, Amusquivar E, López-Soldado I, Ortega H

Blood ketone monitoring: a comparison between gestational diabetes and non-diabetic pregnant women

Author(s): Gin H, Vambergue A, Vasseur C, Rigalleau V, Dufour P, et al.

Determination of free L-carnitine levels in type II diabetic women with and without complications

Author(s): Poorabbas A, Fallah F, Bagdadchi J, Mahdavi R, Aliasgarzadeh A, et al.

Oxidative metabolism in insulin-treated gestational diabetes mellitus

Author(s): Hsu HW, Butte NF, Wong WW, Moon JK, Ellis KJ, et al.

Expression, localization, and function of the carnitine transporter octn2 (slc22a5) in human placenta

Author(s): Grube M, Meyer Zu Schwabedissen H, Draber K, Präger D, Möritz KU, et al.

High activity of fatty acid oxidation enzymes in human placenta: implications for fetal-maternal disease

Author(s): Oey NA, den Boer ME, Ruiter JP, Wanders RJ, Duran M, et al.

Long-chain fatty acid oxidation during early human development

Author(s): Oey NA, den Boer ME, Wijburg FA, Vekemans M, Augé J, et al.