Author(s): Pahor M, Psaty BM, Alderman MH, Applegate WB, Williamson JD, et al.
Objective: To assess whether ACE inhibitors are superior to alternative agents for the prevention of cardiovascular events in patients with hypertension and type 2 diabetes.
Research design and methods: This study is a review and meta-analysis of randomized controlled trials that included patients with type 2 diabetes and hypertension who were randomized to an ACE inhibitor or an alternative drug, were followed for > or =2 years, and had adjudicated cardiovascular events.
Results: A total of 4 trials were eligible. The Appropriate Blood Pressure Control in Diabetes (ABCD) trial (n = 470) compared enalapril with nisoldipine, the Captopril Prevention Project (CAPPP) (n = 572) compared captopril with diuretics or beta-blockers, the Fosinopril Versus Amlodipine Cardiovascular Events Trial (FACET) (n = 380) compared fosinopril with amlodipine, and the U.K. Prospective Diabetes Study (UKPDS) (n = 758) compared captopril with atenolol. The cumulative results of the first 3 trials showed a significant benefit of ACE inhibitors compared with alternative treatments on the outcomes of acute myocardial infarction (63% reduction, P < 0.001), cardiovascular events (51% reduction, P < 0.001), and all-cause mortality (62% reduction, P = 0.010). These findings were not observed in the UKPDS. The ACE inhibitors did not appear to be superior to other agents for the outcome of stroke in any of the trials. None of the findings were explained by differences in blood pressure control.
Conclusions: Compared with the alternative agents tested, ACE inhibitors may provide a special advantage in addition to blood pressure control. The question of whether atenolol is equivalent to captopril remains open. Conclusive evidence on the comparative effects of antihypertensive treatments will come from large prospective randomized trials.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/10895836
Author(s): Ponte C
Author(s): Mensing C, Boucher J, Cypress M, Weinger K, Mulcaby K, et al.
Author(s): Parving HH, Lehnert H, Bröchner-Mortensen J, Gomis R, Andersen S, et al.
Author(s): Foreyt JP, Poston WS 2nd
Author(s): Baliga BS, Fonseca VA (l997) Recent advances in the treatment of type II diabetes mellitus
Author(s): Bailey CJ, Turner RC
Author(s): Mann JF
Author(s): Stang M, Wysowski DK, Butler-Jones D
Author(s): Whittemore R
Author(s): Wing RR, Anglin K
Author(s): DeFronzo RA
Author(s): Wen LK, Shepherd MD, Parchaman ML
Author(s): Savoca MR, Miller CK, Quandt SA
Author(s): Turner R, Cull C, Holman R
Author(s): Arc A, Korhonen T, Halinen M
Author(s): Somogyi A, Stockley C, Keal J, Rolan P, Bockner F (1 987) Reduction of metformin renal tubular secretion by cimetidine in man
Author(s): Lubbos H, Miller JL, Rose LI
Author(s): Yeap BB
Author(s): Kubacka RT, Antal EJ, Juhi RP, Weishman IR (1 996) Effects of aspirin and ibuprofen on the pharmacokinetics and pharmacodynamics of glyburide in healthy subjects
Author(s): Christensen LK, Hansen J, Kristensen M
Author(s): Kivisto KT, Neuvonen PJ
Author(s): Ben-Ami H, Nagachandran P, Mendelson A, Edoute Y
Author(s): Nelson KM, Reiber G, Boyko EJ, Nhanes III
Author(s): Huang CL, Wu SC, Jeng CY, Lin LC
Author(s): Hurley CC, Shea CA
Author(s): Aljasem LI, Peyrot M, Wissow L, Rubin RR
Author(s): Diabetes Control and Complications Trial Research Group
Author(s): Ohkubo Y, Kishikawa H, Araki E, Myata T, Isami S, et al.
Author(s): Swift CS, Armstrong JE, Berman KA, Cambell RK, Pond-Smith D
Author(s): Polit DF, Hungler BP
Author(s): Gerich JE, Odawara M, Terauchi Y
Author(s): Bergenstal RM, Gavin JR, Global Consensus conference on Glucose monitoring panel
Author(s): Renard E
Author(s): Tan MY, Magarey J
Author(s): Mastura I, Mimi O, Piterman L, Teng CL, Wijesinha S
Author(s): Ismail IS, Nazaimoon W, Mohamad W, Letchuman R, Hew FL, et al.
Author(s): Samuel-Hodge CD, Fernandez LM, Henrfquez-Roldan CF, Johnston LF, Keyserling TC
Author(s): Subar AF, Kipnis V, Troiano RP, Midthune D, Schoeller DA, et al.
Author(s): Boehm S, Schlenk EA, Funnell MM, Powers H, Ronis DL
Author(s): Travis T
Author(s): Wen LK, Parchman ML, Shepherd MD
Author(s): Bantle JP, Wylie-Rosett J, Albright AL, Apovian CM, Clark NG, et al.
Author(s): Nutrition sub-committee of the diabetes Care Advisory Committee of Diabetes UK
Author(s): Stein CJ, Colditz GA
Author(s): Hadaegh F, Ghasemi A, Padyab M, Tohidi M, Azizi F
Author(s): Dalgård C, Thurøe A, Haastrup B, Haghfelt T, Stender S
Author(s): Christian JG, Bessesen DH, Byers TE, Christian KK, Goldstein MG, et al.
Author(s): Heshka S, Greenway F, Anderson JW, Atkinson RL, Hill JO, et al.
Author(s): Farmer J
Author(s): Cefalu WT
Author(s): Plosker G, Faulds D
Author(s): Caldwell MA, Peters Kj, Dracup KA
Author(s): Vincent D, Pasvogel A, Barrera L
Author(s): Tan SL, Yong LS, Wan S, Wong ML
Author(s): Hawthone K
Author(s): Middlekoop B, van der Wal G
Author(s): Kulzer B, Hermanns n, Reinecker H, Haak T
Author(s): Clark M, Hampson SE, Avery L, Simpson R
Author(s): Brown S
Author(s): Deakin T, Cade J, Williams R, Greenwood D
Author(s): Raji A, Gomes H, Beard JO, MacDonald P, Conlin PR
Author(s): Clement S
Author(s): Elasy T, Ellis S, Brown A, Pichert J
Author(s): Rubin RR
Author(s): Evans J, Newton R, Ruta D, MacDonald T, Stevenson R, et al.
Author(s): Rhee MK, Slocum W, Ziemer DC, Culler SD, Cook CB, et al.
Author(s): Murata G, Shah J, Duckworth W, Wendel C, Mohler M, et al.
Author(s): Krass I, Armour CL, Mitchell B, Brilliant M, Dienaar R, et al.
Author(s): Suppapitiporn S, Chindavijak B, Onsanit S
Author(s): Welschen LM, Bloemendal E, Nijpels G, Dekker J, Heine RJ, et al.
Author(s): Arcury TA, Preisser JS, Gesler WM, Powers JM
Author(s): Strauss K, MacLean C, Troy A, Littenberg B
Author(s): Westaway MS, Seager JR, Rheeder P, Van Zyl DG
Author(s): Khoo KL, Liew YM, Tan H, Sambhi JS, Hatijah BA
Author(s): Leong KC, Chen WS, Leong KW, Mastura I, Mimi O, et al.