Visfatin: a putative biomarker for metabolic syndrome is not influenced by pioglitazone or simvastatin treatment in nondiabetic patients at cardiovascular risk -- results from the PIOSTAT study

Author(s): Pfutzner A, Hanefeld M, Lübben G, Weber MM, Karagiannis E, et al.


Objective: The aim of the study was to analyze the effect of pioglitazone (PIO) and simvastatin (SIMVA) on adiponectin and visfatin concentrations in nondiabetic patients with metabolic syndrome and increased risk for cardiovascular complications in a prospective randomized clinical trial.

Research design and methods: One-hundred twenty-five nondiabetic patients with increased cardiovascular risk [78 females, 47 males, age (mean+/-STD:58.6+/-7.8years, BMI:30.8+/-4.2(kg/m2] were included after randomization to PIO+lacebo, SIMVA+placebo, or PIO+SIMVA treatment for 3 months. At baseline and endpoint, measurements of HbA1c, glucose, insulin, LDL cholesterol, adiponectin and visfatin were performed. Insulin resistance was assessed by means of the HOMAIR-score.

Results: Improvement in the HOMAIR-score was observed with PIO and the combination, but not with SIMVA alone, which was accompanied by an increase in adiponectin with PIO treatment groups, but a decrease with SIMVA alone (baseline/endpoint: PIO: 14.0+/-8.2 mg/l/ 27.6+/- 14.5 mg/l, p<0.05; PIO+SIMVA: 11.7+/-10.0 mg/l/26.7+/-15.7 mg/l, p<0.05; SIMVA: 15.5+/-12.7 mg/l/ 11.6+/-7.0 mg/l, p<0.05). No change could be observed in the visfatin concentrations (PIO: 47.6+/-14.5 ng/ml/48.0+/-11.6 ng/ml, PIO+SIMVA: 45.1+/-10.9 ng/ml/47.9+/-10.1 ng/ml, SIMVA: 49.2+/- 13.4 ng/ml/52.1+/-16.7 ng/ml, n. s. in all cases).

Conclusions: Insulin resistance and/or cardiovascular risk indicators were not associated with visfatin levels. Regulation of visfatin secretion occurs through biochemical pathways independent from those influenced by pioglitazone or simvastatin.

Similar Articles

Visfatin/PBEF and Atherosclerosis-Related Diseases

Author(s): Filippatos TD, Randeva HS, Derdemezis CS, Elisaf MS, Mikhailidis DP

Age of onset and type of diabetes

Author(s): Laakso M, Pyorala K

Sibutramine and L-carnitine compared to sibutramine alone on insulin resistance in diabetic patients

Author(s): Derosa G, Maffioli P, Salvadeo SA, Ferrari I, Gravina A, et al.

Leptin increase is associated with markers of the hemostatic system in obese healthy women

Author(s): Guagnano MT, Romano M, Falco A, Nutini M, Marinopiccoli M, et al.

Effect of exercise training on plasma visfatin and eotaxin levels

Author(s): Choi KM, Kim JH, Cho GJ, Baik SH, Park HS, et al.

Plasma visfatin concentration as a surrogate marker for visceral fat accumulation in obese children

Author(s): Araki S, Dobashi K, Kubo K, Kawagoe R, Yamamoto Y, et al.

An evaluation of visfatin levels in obese subjects

Author(s): Kaminska A, Kopczynska E, Bronisz A, Zmudzinska M, Bielinski M, et al.

Increased plasma visfatin concentrations in morbidly obese subjects are reduced after gastric banding

Author(s): Haider DG, Schindler K, Schaller G, Prager G, Wolzt M, et al.

Plasma visfatin concentrations in severely obese subjects are increased after intestinal bypass

Author(s): García-Fuentes E, García-Almeida JM, García-Arnés J, García-Serrano S, Rivas-Marín J, et al.

The visfatin gene is associated with glucose and lipid metabolism in a Chinese population

Author(s): Jian WX, Luo TH, Gu YY, Zhang HL, Zheng S et al.

Serum visfatin increases with progressive beta-cell deterioration

Author(s): López-Bermejo A, Chico-Julià B, Fernàndez-Balsells M, Recasens M, Esteve E, et al.

Adipose tissue as an endocrine organ

Author(s): Kershaw EE, Flier JS

Obesity, hypertension and insulin resistance

Author(s): Sharma AM, Chetty VT

Regulation of adipocytokines and insulin resistance

Author(s): Fasshauer M, Paschke R