Evaluation of a single session with cooling garment for persons with multiple sclerosis--a randomized trial

Author(s): Nilsagård Y, Denison E, Gunnarsson LG


Purpose:This research investigates the objective and subjective effects of wearing the Rehband cooling garment.

Method:A multi-centre, randomized crossover study was conducted regarding 43 heat-sensitive persons with multiple sclerosis (MS), comparing active treatment with placebo. Subjects were tested immediately before and after intervention. Ten-(10TW) and 30-metre timed walk (30TW), oral temperature, spasticity, standing balance and timed up and go (TUG) and nine-hole peg test (NHPT) performance were measured. A study-specific questionnaire was used to evaluate subjective experiences.

Results:Active treatment produced statistically significant objective improvement in 10TW, 30TW, one-legged stance, tandem stance (right) and TUG; statistically significant subjective improvement was also found in fatigue, spasticity, weakness, balance, gait, transfers, ability to think clearly and time to recover. The coherence between the objective and subjective results indicates clinical relevance from the subjects' perspective. There were no statistically significant differences between treatments in terms of oral temperature, spasticity (measured by the modified Ashworth scale), tandem stance (left), step test or NHPT, or subjective signs such as difficulty in dressing, dysarthria or pain.

Conclusions:Active cooling with a Rehband: vest is likely to have a positive effect on everyday life in heat-sensitive persons with MS.

Similar Articles

Multiple sclerosis-associated fatigue

Author(s): Krupp LB, Serafin DJ, Christodoulou C

Origin of fatigue in multiple sclerosis: review of the literature

Author(s): Kos D, Kerckhofs E, Nagels G, D'hooghe MB, Ilsbroukx S

Multiple sclerosis and the autonomic nervous system

Author(s): Merkelbach S, Haensch CA, Hemmer B, Koehler J, König NH, et al.

Fatigue in multiple sclerosis is closely related to sleep disorders: a polysomnographic cross-sectional study

Author(s): Veauthier C, Radbruch H, Gaede G, Pfueller CF, Dörr J, et al.

Differential item functioning of the Functional Independence Measure in higher performing neurological patients

Author(s): Dallmeijer AJ, Dekker J, Roorda LD, Knol DL, van Baalen B, et al.

Longitudinal assessment of anxiety, depression, and fatigue in people with multiple sclerosis

Author(s): Brown RF, Valpiani EM, Tennant CC, Dunn SM, Sharrock M, et al.

Cardiovascular autonomic dysfunction in multiple sclerosis: correlation with orthostatic intolerance

Author(s): Flachenecker P, Wolf A, Krauser M, Hartung HP, Reiners K

Thermoregulation in multiple sclerosis

Author(s): Davis SL, Wilson TE, White AT, Frohman EM

A randomized controlled study of the acute and chronic effects of cooling therapy for MS

Author(s): Schwid SR, Petrie MD, Murray R, Leitch J, Bowen J, et al.

Effect of precooling on physical performance in multiple sclerosis

Author(s): White AT, Wilson TE, Davis SL, Petajan JH

Heart rate variability in multiple sclerosis during a stable phase

Author(s): Monge-Argilés JA, Palacios-Ortega F, Vila-Sobrino JA, Matias-Guiu J

A randomized controlled study of the acute and chronic effects of cooling therapy for MS

Author(s): Schwid SR, Petrie MD, Murray R, Leitch J, Bowen J, et al.

Head pre-cooling improves symptoms of heat-sensitive multiple sclerosis patients

Author(s): Reynolds LF, Short CA, Westwood DA, Cheung SS

Cooling garment treatment in MS: clinical improvement and decrease in leukocyte NO production

Author(s): Beenakker EA, Oparina TI, Hartgring A, Teelken A, Arutjunyan AV, et al.