Is speed of processing or working memory the primary information processing deficit in multiple sclerosis? Journal of Clinical and Experimental Neuropsychology 26: 550-56

Author(s): DeLuca J, Chelune, GJ, Tulsky DS, Lengenfelder J, Chiaravalloti ND


Objective:To examine whether processing speed or working memory is the primary information processing deficit in persons with MS.

Design:Case-control study.

Setting:Hospital-based specialty clinic.

Participants:215 adults with clinically definite MS.

Main outcome measure:Mean demographically corrected T-scores, prevalence rates of impairment and relative risk of impaired Processing Speed and Working Memory Index Scores from the WAIS-WMS III.

Results:Deficits in Processing Speed were much more common than Working Memory in all comparisons. This was observed for both relapsing remitting (RRMS) and secondary progressive MS (SPMS) subjects, but accentuated in the latter group.

Conclusions:Results strongly suggest that the primary information processing deficit in persons with MS is in speed of processing.

Similar Articles

Clinical significance of atrophy and white matter mean diffusivity within the thalamus of multiple sclerosis patients

Author(s): Benedict RH, Hulst HE, Bergsland N, Schoonheim MM, Dwyer MG, et al.

Neuropsychological aspects of multiple sclerosis

Author(s): Brassington JC, Marsh NV

Slowed information processing in multiple sclerosis

Author(s): Litvan I, Grafman J, Vendrell P, Martinez JM

Cognitive impairment in three subtypes of multiple sclerosis

Author(s): Denney DR, Sworowski LA, Lynch SG

Automatic memory processes in patients with multiple sclerosis

Author(s): Grafman J, Rao S, Bernardin L, Leo GJ

Clock drawing errors in dementia: neuropsychological and neuroanatomical considerations

Author(s): Cosentino S, Jefferson A, Chute DL, Kaplan E, Libon DJ

Further analyses of clock drawings among demented and nondemented older subjects

Author(s): Libon DJ, Malamut BL, Swenson R, Sands LP, Cloud BS

Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria"

Author(s): Polman CH, Reingold SC, Edan G, Filippi M, Hartung HP, et al.

Leukoaraiosis severity and list-learning in dementia

Author(s): Price CC, Garrett KD, Jefferson AL, Cosentino S, Tanner JJ, et al.

Brain activity during the Clock-Drawing Test: multichannel near-infrared spectroscopy study

Author(s): Shoyama M, Nishioka T, Okumura M, Kose A, Tsuji T, et al.