Author(s): Minden SL
Emotional disturbances are common in MS and consist of disturbances of mood and disturbances of affect. The important mood disorders are major depressive disorder, dysthymic disorder, bipolar disorder, panic disorder, and generalized anxiety disorder. Their relationship to MS is multi-factorial and complex, and the extent to which they are direct consequences of the disease process or psychological reactions to it remains unclear. Whatever their cause, however, the symptoms of mood disorders in people with MS are no different from the symptoms of mood disorders in people without MS, and respond just as well to standard treatments. The disorders of affect are euphoria, pathological laughing and weeping, and other frontal lobe syndromes. These disorders result from demyelination, are some of the most characteristic symptoms of MS, and have the same implications for treatment as do other aspects of the disease. Mood and affective disturbances can cause enormous pain and suffering and lead to significant disruption of family, work, and social life. Physicians who can identify, diagnose, treat, and manage mood and affective disturbances effectively and who can help their patients and family members acknowledge these difficulties, talk about them, and accept psychiatric consultation and treatment can have a dramatic impact on the quality of their lives. This paper outlines the symptoms and diagnostic criteria for mood disorders and affective disturbances, reviews current treatment options, summarizes data from epidemiologic and pathophysiological studies, and suggests areas for future research.
Referred From: https://pubmed.ncbi.nlm.nih.gov/10871806/
Author(s): Nocentini U, Tedeschi G, Migliaccio R, Dinacci D, Lavorgna L, et al.
Author(s): Ghaffar O, Feinstein A
Author(s): Feinstein A, Feinstein K
Author(s): Nortvedt MW, Riise T
Author(s): Mittleman MA, Maclure M, Sherwood JB, Mulry RP, Tofler GH, et al.
Author(s): van Middendorp H, Geenen R, Sorbi MJ, Hox JJ, Vingerhoets AJ, et al.
Author(s): Lopes PN, Salovey P, Coté S, Beers M
Author(s): Gross JJ
Author(s): Abel GM
Author(s): Gerin W, Davidson KW, Christenfeld NJ, Goyal T, Schwartz JE
Author(s): Rusting CL, Nolen-Hoeksema S
Author(s): van Middendorp H, Lumley MA, Moerbeek M, Jacobs JW, Bijlsma JW, et al.
Author(s): Fernandez E, Turk DC
Author(s): Okifuji A, Turk DC, Curran SL
Author(s): Lima FS, Simioni S, Bruggimann L, Ruffieux C, Dudler J, et al.
Author(s): Feinstein A
Author(s): Siegert RJ, Abernethy DA
Author(s): Minden SL, Orav J, Reich P
Author(s): Deschênes SS, Dugas MJ, Fracalanza K, Koerner N
Author(s): Skevington SM, Lotfy M, O’Connell KA
Author(s): Alshubaili AF, Awadalla AW, Ohaeri JU, Mabrouk AA
Author(s): Phillips LH, Henry JD, Hosie JA, Milne AB
Author(s): Hohol MJ, Orav EJ, Weiner HL
Author(s): Kurtzke JF
Author(s): Learmonth YC, Motl RW, Sandroff BM, Pula JH, Cadavid D
Author(s): Phillips LH, Henry JD, Nouzova E, Cooper C, Radlak B, et al.
Author(s): Phillips LH, Henry JD, Scott C, Summers F, Whyte M, et al.
Author(s): Phillips LH, Saldias A, McCarrey A, Henry JD, Scott C, et al.