Author(s): Tomassini V, Matthews PM, Thompson AJ, Fuglø D, Geurts JJ, et al.
The development of therapeutic strategies that promote functional recovery is a major goal of multiple sclerosis (MS) research. Neuroscientific and methodological advances have improved our understanding of the brain's recovery from damage, generating novel hypotheses about potential targets and modes of intervention, and laying the foundation for development of scientifically informed recovery-promoting strategies in interventional studies. This Review aims to encourage the transition from characterization of recovery mechanisms to development of strategies that promote recovery in MS. We discuss current evidence for functional reorganization that underlies recovery and its implications for development of new recovery-oriented strategies in MS. Promotion of functional recovery requires an improved understanding of recovery mechanisms that can be modulated by interventions and the development of robust measurements of therapeutic effects. As imaging methods can be used to measure functional and structural alterations associated with recovery, this Review discusses their use to obtain reliable markers of the effects of interventions.
Referred From: https://pubmed.ncbi.nlm.nih.gov/22986429/
Author(s): Genova HM, Hillary FG, Wylie G, Rypma B, Deluca J
Author(s): Chiaravalloti N, Hillary F, Ricker J, Christodoulou C, Kalnin A, et al.
Author(s): Sumowski JF, Wylie GR, Leavitt VM, Chiaravalloti ND, Deluca J
Author(s): Pantano P, Iannetti GD, Caramia F, Mainero C, Di Legge S, et al.
Author(s): Hillary FG, Chiaravalloti N, Ricker JH, Steffener J, Bly BM, et al.
Author(s): Pantano P, Mainero C, Iannetti GD, Caramia F, Di Legge S, et al.
Author(s): Staffen W, Zauner H, Mair A, Kutzelnigg A, Kapeller P, et al.
Author(s): Kirov II, Tal A, Babb JS, Herbert J, Gonen O
Author(s): Kirov II, Patil V, Babb JS, Rusenek H, Herbert J, et al.
Author(s): Sajja BR, Wolinsky JS, Narayana PA
Author(s): De Stefano N, Filippi M, Miller D, Pouwels PJ, Rovira a, et al.
Author(s): Llufriu S, Kornak J, Ratiney H, Oh J, Brenneman D, et al.
Author(s): Lee M, Reddy H, Johansen-Berg H, Pendlebury S, Jenkinson M, et al.
Author(s): Mainero C, Caramia F, Pozzilli C, Pisani A, Pestalozza I, et al.
Author(s): Reddy H, Narayanan S, Woolrich M, Mitsumori T, Arnold DL, et al.
Author(s): Reddy H, Narayanan S, Arnoutelis R, Jenkinson M, Antel J, et al.
Author(s): Van Schependom J, D’hooghe MB, Cleynhens K, D’hooge M, Haelewyck M-C, et al.
Author(s): Reddy H, Narayanan S, Matthews PM, Hoge RD, Pike GB, et al.
Author(s): Inglese M, Li BSY, Rusinek H, Babb JS, Grossman RI, et al.
Author(s): McDonald WI, Compston a, Edan G, Goodkin D, Hartung HP, et al.
Author(s): Ashburner J, Neelin P, Collins DL, Evans A, Friston K
Author(s): Cox RW
Author(s): Gonen O, Murdoch JB, Stoyanova R, Goelman G
Author(s): Soher BJ, Young K, Govindaraju V, Maudsley AA
Author(s): Lynch J, Peeling J, Auty A, Sutherland GR
Author(s): Mikheev A, Nevsky G, Govindan S, Grossman R, Rusinek H
Author(s): Sled JG, Zijdenbos AP, Evans AC
Author(s): Kirov II, Patil V, Babb JS, Rusinek H, Herbert J, et al.
Author(s): Li BS, Wang H, Gonen O
