Author(s): Learmonth YC, Motl RW, Sandroff BM, Pula JH, Cadavid D
Background:The Patient Determined Disease Steps (PDDS) is a promising patient-reported outcome (PRO) of disability in multiple sclerosis (MS). To date, there is limited evidence regarding the validity of PDDS scores, despite its sound conceptual development and broad inclusion in MS research. This study examined the validity of the PDDS based on (1) the association with Expanded Disability Status Scale (EDSS) scores and (2) the pattern of associations between PDDS and EDSS scores with Functional System (FS) scores as well as ambulatory and other outcomes.
Methods:96 persons with MS provided demographic/clinical information, completed the PDDS and other PROs including the Multiple Sclerosis Walking Scale-12 (MSWS-12), and underwent a neurological examination for generating FS and EDSS scores. Participants completed assessments of cognition, ambulation including the 6-minute walk (6 MW), and wore an accelerometer during waking hours over seven days.
Results:There was a strong correlation between EDSS and PDDS scores (ρ = .783). PDDS and EDSS scores were strongly correlated with Pyramidal (ρ = .578 &ρ = .647, respectively) and Cerebellar (ρ = .501 &ρ = .528, respectively) FS scores as well as 6 MW distance (ρ = .704 &ρ = .805, respectively), MSWS-12 scores (ρ = .801 &ρ = .729, respectively), and accelerometer steps/day (ρ = -.740 &ρ = -.717, respectively).
Conclusion:This study provides novel evidence supporting the PDDS as valid PRO of disability in MS.
Referred From: https://pubmed.ncbi.nlm.nih.gov/23617555/
Author(s): Nocentini U, Tedeschi G, Migliaccio R, Dinacci D, Lavorgna L, et al.
Author(s): Ghaffar O, Feinstein A
Author(s): Minden SL
Author(s): Feinstein A, Feinstein K
Author(s): Nortvedt MW, Riise T
Author(s): Mittleman MA, Maclure M, Sherwood JB, Mulry RP, Tofler GH, et al.
Author(s): van Middendorp H, Geenen R, Sorbi MJ, Hox JJ, Vingerhoets AJ, et al.
Author(s): Lopes PN, Salovey P, Coté S, Beers M
Author(s): Gross JJ
Author(s): Abel GM
Author(s): Gerin W, Davidson KW, Christenfeld NJ, Goyal T, Schwartz JE
Author(s): Rusting CL, Nolen-Hoeksema S
Author(s): van Middendorp H, Lumley MA, Moerbeek M, Jacobs JW, Bijlsma JW, et al.
Author(s): Fernandez E, Turk DC
Author(s): Okifuji A, Turk DC, Curran SL
Author(s): Lima FS, Simioni S, Bruggimann L, Ruffieux C, Dudler J, et al.
Author(s): Feinstein A
Author(s): Siegert RJ, Abernethy DA
Author(s): Minden SL, Orav J, Reich P
Author(s): Deschênes SS, Dugas MJ, Fracalanza K, Koerner N
Author(s): Skevington SM, Lotfy M, O’Connell KA
Author(s): Alshubaili AF, Awadalla AW, Ohaeri JU, Mabrouk AA
Author(s): Phillips LH, Henry JD, Hosie JA, Milne AB
Author(s): Hohol MJ, Orav EJ, Weiner HL
Author(s): Kurtzke JF
Author(s): Phillips LH, Henry JD, Nouzova E, Cooper C, Radlak B, et al.
Author(s): Phillips LH, Henry JD, Scott C, Summers F, Whyte M, et al.
Author(s): Phillips LH, Saldias A, McCarrey A, Henry JD, Scott C, et al.