Near-infrared resonant nanoshells for combined optical imaging and photothermal cancer therapy

Author(s): Gobin AM, Lee MH, Halas NJ, James WD, Drezek RA, et al.

Abstract

Metal nanoshells are core/shell nanoparticles that can be designed to either strongly absorb or scatter within the near-infrared (NIR) wavelength region ( approximately 650-950 nm). Nanoshells were designed that possess both absorption and scattering properties in the NIR to provide optical contrast for improved diagnostic imaging and, at higher light intensity, rapid heating for photothermal therapy. Using these in a mouse model, we have demonstrated dramatic contrast enhancement for optical coherence tomography (OCT) and effective photothermal ablation of tumors.

Similar Articles

Folic acid-CdTe quantum dot conjugates and their applications for cancer cell targeting

Author(s): Suriamoorthy P, Zhang X, Hao G, Joly AG, Singh S, et al.

A method to predict breast cancer stage using Medicare claims

Author(s): Smith GL, Shih YC, Giordano SH, Smith BD, Buchholz TA

Toxic potential of materials at the nanolevel

Author(s): Nel A, Xia T, M├Ądler L, Li N

From nanotechnology to nanomedicine: applications to cancer research

Author(s): Seigneuric R, Markey L, Nuyten DS, Dubernet C, Evelo CT, et al.

Superparamagnetic iron oxide nanoparticle probes for molecular imaging

Author(s): Thorek DL, Chen AK, Czupryna J, Tsourkas A

Freeze-drying of nanoparticles: formulation, process and storage considerations

Author(s): Abdelwahed W, Degobert G, Stainmesse S, Fessi H

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

Author(s): Koopman G, Reutelingsperger CP, Kuijten GA, Keehnen RM, Pals ST, et al.

Synthesis of gold nanotriangles and silver nanoparticles using Aloe vera plant extract

Author(s): Chandran SP, Chaudhary M, Pasricha R, Ahmad A, Sastry M

Facile green synthesis of variable metallic gold nanoparticle using Padinagymnospora, a brown marine macroalga

Author(s): Singh M, Kalaivani R, Manikandan S, Sangeetha N, Kumaraguru AK

Gold nanoparticles: From nanomedicine to nanosensing

Author(s): Chen PC, Mwakwari SC, Oyelere AK

Biological applications of gold nanoparticles

Author(s): Sperling RA, Rivera Gil P, Zhang F, Zanella M, Parak WJ

Gold nanoparticles for biology and medicine

Author(s): Giljohann DA, Seferos DS, Daniel WL, Massich MD, Patel PC, et al.

Reperfusion induces myocardial apoptotic cell death

Author(s): Zhao ZQ, Nakamura M, Wang NP, Wilcox JN, Shearer S, et al.

Asbestos causes apoptosis in alveolar epithelial cells: role of iron-induced free radicals

Author(s): Aljandali A, Pollack H, Yeldandi A, Li Y, Weitzman SA, et al.

Distinct cytotoxic mechanisms of pristine versus hydroxylated fullerene

Author(s): Isakovic A, Markovic Z, Todorovic-Markovic B, Nikolic N, Vranjes-Djuric S, et al.

In vitro testing of the potential for orthopedic bone cements to cause apoptosis of osteoblast-like cells

Author(s): Ciapetti G, Granchi D, Savarino L, Cenni E, Magrini E, et al.