Auditory cortical activity in amnestic mild cognitive impairment: relationship to subtype and conversion to dementia

Author(s): Golob EJ, Irimajiri R, Starr A


Mild cognitive impairment (MCI) patients have a high risk of converting to Alzheimer's disease. The most common diagnostic subtypes of MCI have an episodic memory disorder (amnestic MCI) occurring either alone [single domain (SD)] or with other cognitive impairments [multiple domain (MD)]. Previous studies report increased amplitudes of auditory cortical potentials in MCI, but their relationships to MCI subtypes and clinical outcomes were not defined. We studied subjects with amnestic MCI (n = 41: 28 SD, 13 MD), Alzheimer's disease (n = 14), and both younger (n = 22) and age-matched older controls (n = 44). Baseline auditory sensory (P50, N100) and cognitive potentials (P300) were recorded during an auditory discrimination task. MCI patients were followed for up to 5 years, and outcomes were classified as (i) continued diagnosis of MCI (MCI-stable, n = 16), (ii) probable Alzheimer's disease (MCI-convert, n = 18), or other outcomes (n = 7). Auditory potentials were analysed as a function of MCI diagnosis and outcomes, and compared with young, older controls, and mild Alzheimer's disease subjects. P50 amplitude increased with normal ageing, and had additional increases in MCI as a function of both initial diagnosis (MD > than SD) and outcome (MCI-convert > MCI-stable). P300 latency increased with normal ageing, and had additional increases in MCI but did not differ among outcomes. We conclude that auditory cortical sensory potentials differ among amnestic MCI subtypes and outcomes occurring up to 5 years later.

Similar Articles

Mild cognitive impairment: clinical characterization and outcome

Author(s): Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, et al.

Mild cognitive impairment: an overview

Author(s): Petersen RC, Negash S

Current concepts in mild cognitive impairment

Author(s): Petersen RC, Doody R, Kurz A, Mohs RC, Morris JC, et al.

Mild cognitive impairment: ten years later

Author(s): Petersen RC, Roberts RO, Knopman DS, Boeve BF, Geda YE, et al.

Feasibility of lumbar puncture in the study of cerebrospinal fluid biomarkers for Alzheimer's disease: a multicenter study in Spain

Author(s): Alcolea D, Martínez-Lage P, Izagirre A, Clerigué M, Carmona-Iragui M, et al.

The functional neuroanatomy of target detection: an fMRI study of visual and auditory oddball tasks

Author(s): Linden DE, Prvulovic D, Formisano E, Völlinger M, Zanella FE, et al.

Usefulness of p300 in subjective memory complaints: a prospective study

Author(s): Gironell A, García-Sánchez C, Estévez-González A, Boltes A, Kulisevsky J

P300 latency and amplitude in Alzheimer's disease: a systematic review

Author(s): Pedroso RV, Fraga FJ, Corazza DI, Andreatto CA, Coelho FG, et al.

Usefulness of event-related potentials in the assessment of mild cognitive impairment

Author(s): Papaliagkas V, Kimiskidis V, Tsolaki M, Anogianakis G

Cognitive event-related potentials: longitudinal changes in mild cognitive impairment

Author(s): Papaliagkas VT, Kimiskidis VK, Tsolaki MN, Anogianakis G