Author(s): Golob EJ, Irimajiri R, Starr A
Mild cognitive impairment (MCI) patients have a high risk of converting to Alzheimer's disease. The most common diagnostic subtypes of MCI have an episodic memory disorder (amnestic MCI) occurring either alone [single domain (SD)] or with other cognitive impairments [multiple domain (MD)]. Previous studies report increased amplitudes of auditory cortical potentials in MCI, but their relationships to MCI subtypes and clinical outcomes were not defined. We studied subjects with amnestic MCI (n = 41: 28 SD, 13 MD), Alzheimer's disease (n = 14), and both younger (n = 22) and age-matched older controls (n = 44). Baseline auditory sensory (P50, N100) and cognitive potentials (P300) were recorded during an auditory discrimination task. MCI patients were followed for up to 5 years, and outcomes were classified as (i) continued diagnosis of MCI (MCI-stable, n = 16), (ii) probable Alzheimer's disease (MCI-convert, n = 18), or other outcomes (n = 7). Auditory potentials were analysed as a function of MCI diagnosis and outcomes, and compared with young, older controls, and mild Alzheimer's disease subjects. P50 amplitude increased with normal ageing, and had additional increases in MCI as a function of both initial diagnosis (MD > than SD) and outcome (MCI-convert > MCI-stable). P300 latency increased with normal ageing, and had additional increases in MCI but did not differ among outcomes. We conclude that auditory cortical sensory potentials differ among amnestic MCI subtypes and outcomes occurring up to 5 years later.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/17293359
Author(s): Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, et al.
Author(s): Petersen RC
Author(s): Petersen RC, Negash S
Author(s): Petersen RC, Doody R, Kurz A, Mohs RC, Morris JC, et al.
Author(s): Petersen RC, Roberts RO, Knopman DS, Boeve BF, Geda YE, et al.
Author(s): Gauthier S, Scheltens P
Author(s): Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, et al.
Author(s): Alcolea D, Martínez-Lage P, Izagirre A, Clerigué M, Carmona-Iragui M, et al.
Author(s): Campanella S
Author(s): Linden DE, Prvulovic D, Formisano E, Völlinger M, Zanella FE, et al.
Author(s): Polich J, Criado JR
Author(s): Gironell A, García-Sánchez C, Estévez-González A, Boltes A, Kulisevsky J
Author(s): Squires NK, Squires KC, Hillyard SA
Author(s): Pedroso RV, Fraga FJ, Corazza DI, Andreatto CA, Coelho FG, et al.
Author(s): Jiang S, Qu C, Wang F, Liu Y, Qiao Z, et al.
Author(s): Lai CL, Lin RT, Liou LM, Liu CK
Author(s): Papaliagkas V, Kimiskidis V, Tsolaki M, Anogianakis G
Author(s): Papaliagkas VT, Anogianakis G, Tsolaki MN, Koliakos G, Kimiskidis VK
Author(s): Papaliagkas VT, Kimiskidis VK, Tsolaki MN, Anogianakis G
Author(s): Bennys K, Rondouin G, Benattar E, Gabelle A, Touchon J