Author(s): Giannantoni A, Conte A, Proietti S, Giovannozzi S, Rossi A, et al.
Purpose:In this 6-month followup study we investigated the effect of intradetrusor injection of 100 U botulinum toxin type A in patients with Parkinson's disease and refractory detrusor overactivity.
Materials and methods:Eight patients with Parkinson's disease and detrusor overactivity refractory to anticholinergics were injected with 100 U botulinum toxin type A. Daytime and nighttime urinary frequency, and urinary incontinence episodes were recorded. Patients also completed a standardized quality of life questionnaire on incontinence and a visual analog scale on the impact of bladder problems on daily life activities, and underwent urodynamic assessment, including pressure flow studies. Clinical and urodynamic assessment was performed before, and 1, 3 and 6 months after injection.
Results:In all patients 100 U botulinum toxin type A induced decreased daytime and nighttime urinary frequency, a decreased number of urinary incontinence episodes, increased quality of life scores and, as shown by increased maximum cystometric capacity, improved urodynamic findings. In 2 patients with Parkinson's disease post-void residual urine volume developed.
Conclusions:Intradetrusor injection of 100 U botulinum toxin type A induced clinical and urodynamic improvement in overactive bladder symptoms that lasted at least 6 months in patients with Parkinson's disease.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/21791351
Author(s): Fowler CJ, Panicker JN, Drake M, Harris, Harrison SCW, et al.
Author(s): Stoffel JT
Author(s): Phadke JG
Author(s): MahajanST, Patel PB, Marrie RA
Author(s): RuffionA, Castro-Diaz D, Patel H, Khalaf K, Onyenwenyi A, et al.
Author(s): MarrieRA, Cutter G, Tyry T, Vollmer T, Campagnolo D
Author(s): de Sèze M, Ruffion A, Denys P, Joseph PA, Perrouin-Verbe B; GENULF
Author(s): Castel-Lacanal E, Gamé X, Clanet M, Gasq D, De Boissezon X, et al.
Author(s): Fowler CJ, Griffiths D, de Groat WC
Author(s): Williams D
Author(s): Sand PK Sand RI
Author(s): Ruud Bosch JL, Groen J
Author(s): Dillon BE, Seideman CA, Lee D, Greenberg B, Frohman EM, et al.
Author(s): Santos-Silva A, da Silva CM, Cruz F
Author(s): Panicker J, Haslam C
Author(s): Rakusa M, Murphy O, McIntyre L, Porter B, Panicker J, et al.
Author(s): Fletcher SG, Dillon BE, Gilchrist AS, Haverkorn RM, Yan J, et al.
Author(s): De Ridder D, Van Der Aa F, Debruyne J, D'hooghe MB, Dubois B, et al.
Author(s): Amarenco G, Chartier-Kastler E, Denys P, Jean JL, de Seze M et al.
Author(s): Bates D, Burks J, Globe D, Signori M, Hudgens S, et al.
Author(s): Sussman D, Patel V, Del Popolo G, Lam W, Globe D, et al.
Author(s): Koldewijn EL, Hommes OR, Lemmens WA, Debruyne FM, van Kerrebroeck PE
Author(s): McClurg D, Ashe RG, Marshall K, Lowe-Strong AS
Author(s): Ellsworth P, Cone EB
Author(s): Khullar V, Cambronero J, Angulo JC, Wooning M, Blauwet MB, et al.
Author(s): StankovichEIu, Borisov VV, Demina TL
Author(s): Zajicek JP, Apostu VI
Author(s): Kavia RB, De Ridder D, Constantinescu CS, Stott CG, Fowler CJ
Author(s): Freeman RM, Adekanmi O, Waterfield MR, Waterfield AE, Wright D, et al.
Author(s): Brady CM, DasGupta R, Dalton C, Wiseman OJ, Berkley KJ, et al.
Author(s): Tubaro A, Puccini F, De Nunzio C, Digesu GA, Elneil S, et al.
Author(s): Cruz F, Herschorn S, Aliotta P, Brin M, Thompson C, et al.
Author(s): Ghalayini IF, Al-Ghazo MA, Elnasser ZA
Author(s): Ginsberg D, Gousse A, Keppenne V, Sievert KD, Thompson C, et al.
Author(s): Smaldone MC1, Ristau BT, Leng WW
Author(s): Bosch JL
Author(s): Chartier-Kastler EJ, Ruud Bosch JL, Perrigot M, Chancellor MB, Richard F, et al.
Author(s): Kessler TM, La Framboise D, Trelle S, Fowler CJ, Kiss G, et al.
Author(s): Peters KM, Kandagatla P, Killinger KA, Wolfert C, Boura JA
Author(s): Peters KM, Carrico DJ, Wooldridge LS, Miller CJ, MacDiarmid SA
Author(s): Staskin DR, Peters KM, MacDiarmid S, Shore N, de Groat WC
Author(s): Gobbi C, Digesu GA, Khullar V, El Neil S, Caccia G, et al.
Author(s): Mahajan ST, Frasure HE1, Marrie RA2
Author(s): Castel-Lacanal E, Gamé X, De Boissezon X, Guillotreau J, Braley-Berthoumieux E, et al.
Author(s): DeLong J, Tighiouart H, Stoffel J
