Author(s): Uemura M, Kasahara Y, Nagatsuka K, Taguchi A
Cell-based therapies are a novel approach for regeneration of microvasculature. We have shown that administration of CD34-positive cells, the rich cell fraction of endothelial progenitor cells, after stroke induces angiogenesis that results in enhanced endogenous neurogenesis and functional recovery in a murine model. Moreover, injury-induced neurogenesis occurs in the human brain following a stroke during the acute to sub-acute period. Based on these observations, clinical trials of cell therapies that aim to regenerate micro-circulation in the brain following a stroke are ongoing worldwide. This review summarizes the current basic research findings about the link between angiogenesis and neurogenesis in the post-stroke brain and introduces the ongoing clinical trials of cell-based therapies for patients that have suffered a stroke.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/22239630
Author(s): Hung CW, Liou YJ, Lu SW, Tseng LM, Kao CL, et al.
Author(s): Leker RR, McKay RD
Author(s): Nakaguchi K, Masuda H, Kaneko N, Sawamoto K
Author(s): Kaneko Y, Tajiri N, Shinozuka K, Glover LE, Weinbren NL, et al.
Author(s): Gage FH
Author(s): Doetsch F, Caillé I, Lim DA, García-Verdugo JM, Alvarez-Buylla A
Author(s): Iwai M, Sato K, Omori N, Nagano I, Manabe Y, et al.
Author(s): Iwai M, Sato K, Kamada H, Omori N, Nagano I, et al.
Author(s): Arvidsson A, Collin T, Kirik D, Kokaia Z, Lindvall O
Author(s): Teramoto T, Qiu J, Plumier JC, Moskowitz MA
Author(s): Gensert JM, Goldman JE
Author(s): Menn B, Garcia-Verdugo JM, Yaschine C, Gonzalez-Perez O, Rowitch D, et al.
Author(s): Ninomiya M, Yamashita T, Araki N, Okano H, Sawamoto K
Author(s): Türeyen K, Vemuganti R, Bowen KK, Sailor KA, Dempsey RJ
Author(s): Emsley JG, Hagg T
Author(s): Yan YP, Sailor KA, Vemuganti R, Dempsey RJ
Author(s): Zhu W, Cheng S, Xu G, Ma M, Zhou Z, et al.
Author(s): Kako E, Kaneko N, Aoyama M, Hida H, Takebayashi H, et al.
Author(s): Zhang ZG, Zhang L, Jiang Q, Zhang R, Davies K, et al.
Author(s): Hess DC, Hill WD, Martin-Studdard A, Carroll J, Brailer J, et al.
Author(s): Paczkowska E, Kucia M, Koziarska D, Halasa M, Safranow K, et al.
Author(s): Beltrami AP, Barlucchi L, Torella D, Baker M, Limana F, et al.
Author(s): Asahara T, Takahashi T, Masuda H, Kalka C, Chen D, et al.
Author(s): Kalka C, Masuda H, Takahashi T, Gordon R, Tepper O, et al.
Author(s): Sehara Y, Hayashi T, Deguchi K, Zhang H, Tsuchiya A, et al.