Author(s): DeJong W, Petty M
The cardiovascular effects of catecholamines and related substances after local application into the nucleus tractus solitarii (NTS) of the medulla oblongata of urethane anesthetized rats are summarized. The catecholamines in the nanomolar dose range appear to activate stereospecifically receptor sites in the NTS, resulting in a decrease in blood pressure. Bradycardia occurs after bilateral administration of higher doses. The type of catecholaminergic receptors involved is discussed on the basis of the effects of different catecholamine receptor stimulating agents and pharmacological blockade. Both alpha-methylnoradrenaline and alpha-methyladrenaline are active and it is concluded that they both may contribute to the antihypertensive action of alpha-methyldopa. It is probable that an alpha-type of receptor mediates these hypotensive effects in the NTS. The nature of this receptor needs further characterization.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/6175850
Author(s): Bonham AC, McCrimmon DR
Author(s): Housley GD, Sinclair JD
Author(s): Versteeg DH, Van Der Gugten J, De Jong W, Palkovits M
Author(s): Hökfelt T, Johansson O, Fuxe K, Goldstein M, Park D
Author(s): Kitahama K, Denoroy L, Bérod A, Jouvet M
Author(s): Kitahama K, Denoyer M, Raynaud B, Borri-Voltattorni C, Weber M, et al
Author(s): Kitahama K, Buda C, Sastre JP, Nagatsu I, Raynaud B, et al.
Author(s): Smith HR, Beveridge TJ, Porrino LJ
Author(s): Armstrong DM, Ross CA, Pickel VM, Joh TH, Reis DJ
Author(s): Arango V, Ruggiero DA, Callaway JL, Anwar M, Mann JJ, et al.
Author(s): Kitahama K, Pearson J, Denoroy L, Kopp N, Ulrich J, et al.
Author(s): Reiner PB, Vincent SR
Author(s): Tillet Y, Thibault J
Author(s): Levitt P, Moore RY
Author(s): Blessing WW, Frost P, Furness JB
Author(s): Jones BE, Friedman L
Author(s): Poitras D, Parent A
Author(s): Wiklund L, Leger L, Persson M
Author(s): Geffard M, Henrich-Rock AM, Dulluc J, Seguela P
Author(s): Geffard M, Patel S, Dulluc J, Rock AM
Author(s): Fritschy JM, Geffard M, Grzanna R
Author(s): Ikemoto K, Kitahama K, Maeda T, Satoh K
Author(s): Smeets WJ, Gonzalez A
Author(s): Dahlström AB, Czernik AJ, Li JY
Author(s): Kitahama K, Geffard M, Okamura H, Nagatsu I, Mons N, et al
Author(s): Seguela P, Watkins K, Geffard M, Decarries L
Author(s): Loewy AD, Burton H
Author(s): Grzanna R, Berger U, Fritschy JM, Geffard M
Author(s): Barnes KL, Chernicky CL, Block CH, Ferrario CM
Author(s): Kimura H, McGeer PL, Peng JH, McGeer EG
Author(s): Ritchie TC, Westlund KN, Bowker RM, Coulter JD, Leonard RB
Author(s): Swanson LW, Hartman BK
Author(s): Kitahama K, Nagatsu I, Geffard M, Maeda T
Author(s): Ikemoto K, Kitahama K, Maeda T, Tokunaga Y, Valatx JL, et al.
Author(s): Kitahama K, Maeda T, Denney RM, Jouvet M
Author(s): Arai R, Horiike K, Hasegawa Y
Author(s): Sved AF
Author(s): Pau KY, Ma YJ, Yu JH, Yang SP, Airhart N, et al.
Author(s): Westlund KN, Denney RM, Kochersperger LM, Rose RM, Abell CW
Author(s): Westlund KN, Denney RM, Rose RM, Abell CW
Author(s): Kitahama K, Bérod A, Denoyer M, Jouvet M
Author(s): Reader TA, Brière R, Grondin L, Ferron A
Author(s): Koed K, Linnet K
Author(s): Olson EB, Dempsey JA, McCrimmon DR
Author(s): Chiba T, Kato M
Author(s): Shapiro RE, Miselis RR
Author(s): Rukhadze I, Kubin L
Author(s): Ricardo JA, Koh ET
Author(s): Ter Horst GJ, de Boer P, Luiten PG, van Willigen JD
Author(s): Dassesse D, Hemmens B, Cuvelier L, Résibois A
Author(s): Lorang D, Amara SG, Simerly RB
Author(s): Ellenberger HH, Vera PL, Haselton JR, Haselton CL, Schneiderman N
Author(s): Pilowsky PM, Jiang C, Lipski J
Author(s): Champagnat J, Denavit-Saubié M, Henry JL, Leviel V
Author(s): Viemari JC, Ramirez JM
Author(s): Soulier V, Cottet-Emard JM, Pequignot J, Hanchin F, Peyrin L, et al.
Author(s): Dumas S, Pequignot JM, Ghilini G, Mallet J, Denavit-Saubie M
Author(s): Soulier V, Cottet-Emard JM, Dalmaz Y, Kitahama K, Pequignot JM
Author(s): Schmitt P, Soulier V, Péquignot JM, Pujol JF, Denavit-Saubié M
Author(s): Pascual O, Denavit-Saubie M, Dumas S, Kietzmann T, Ghilini G, et al.
Author(s): Semenza GL
Author(s): Schnell PO, Ignacak ML, Bauer AL, Striet JB, Paulding WR, et al.
Author(s): Haxhiu MA, Yung K, Erokwu B, Cherniack NS
Author(s): Bhargava KP, Mishra N, Tangri KK
Author(s): Zandberg P, De Jong W, De Wied D
Author(s): Klausmair A, Singewald N, Philippu A
Author(s): Philippu A, Pfitscher A, Singewald N
Author(s): Sumal KK, Blessing WW, Joh TH, Reis DJ, Pickel VM
Author(s): Gieroba ZJ, Blessing WW
Author(s): Rogers RC, Travagli RA, Hermann GE
Author(s): Reyes BA, Van Bockstaele EJ
Author(s): Yang M, Zhao X, Miselis RR
Author(s): Miceli MO, Malsbury CW
Author(s): Unnerstall JR, Kopajtic TA, Kuhar MJ
Author(s): Akiyama T and Yamazaki T
Author(s): Siaud P, Mekaouche M, Givalois L, Balmefrezol M, Marcilhac A, et al.
