Author(s): Papaliagkas VT, Anogianakis G, Tsolaki MN, Koliakos G, Kimiskidis VK
Background/aims:The aim of this study was to investigate the diagnostic role of CSF beta amyloid(1-42) levels and auditory event-related potentials (AERPs) in the progression of mild cognitive impairment (MCI) to Alzheimer's disease (AD).
Methods:In fifty three MCI patients a lumbar puncture was performed and beta amyloid(1-42) levels were determined. Twenty patients were re-examined after 11 months. During this period five of them progressed to AD. Neuropsychological and ERP examinations were performed in all patients at both exams.
Results:Compared to MCI stable patients, AD-converters showed significantly lower beta-amyloid(1-42) values both for group 1 (Mann Whitney test, Z=-2.952, p=0.003, effect size r=-0.41) and group 2 (Z=-2.458, p=0.011; effect size r=-0.55). On the other hand, the patients of group 1 who converted to AD had prolonged latencies and lower amplitudes of the P300 wave compared to those of the MCI-stable patients, although the differences were not significant.
Conclusions:Compared to the separate use of CSF beta-amyloid(1-42) and AERPs, higher values of sensitivity and specificity were achieved by the combined use of beta-amyloid(1-42) levels and P300 latencies (80% and 98%) or amplitudes (100% and 89%) in the discrimination between AD converters and MCI stable patients. Therefore the combination of an electrophysiological and a biological marker is potentially of high diagnostic value for the early diagnosis of AD converters.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/19939224
Author(s): Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, et al.
Author(s): Petersen RC
Author(s): Petersen RC, Negash S
Author(s): Petersen RC, Doody R, Kurz A, Mohs RC, Morris JC, et al.
Author(s): Petersen RC, Roberts RO, Knopman DS, Boeve BF, Geda YE, et al.
Author(s): Gauthier S, Scheltens P
Author(s): Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, et al.
Author(s): Alcolea D, Martínez-Lage P, Izagirre A, Clerigué M, Carmona-Iragui M, et al.
Author(s): Campanella S
Author(s): Linden DE, Prvulovic D, Formisano E, Völlinger M, Zanella FE, et al.
Author(s): Polich J, Criado JR
Author(s): Gironell A, García-Sánchez C, Estévez-González A, Boltes A, Kulisevsky J
Author(s): Squires NK, Squires KC, Hillyard SA
Author(s): Pedroso RV, Fraga FJ, Corazza DI, Andreatto CA, Coelho FG, et al.
Author(s): Jiang S, Qu C, Wang F, Liu Y, Qiao Z, et al.
Author(s): Lai CL, Lin RT, Liou LM, Liu CK
Author(s): Papaliagkas V, Kimiskidis V, Tsolaki M, Anogianakis G
Author(s): Papaliagkas VT, Kimiskidis VK, Tsolaki MN, Anogianakis G
Author(s): Bennys K, Rondouin G, Benattar E, Gabelle A, Touchon J
Author(s): Golob EJ, Irimajiri R, Starr A