Comparison of ankle-brachial pressure index and pulse wave velocity as markers of cognitive function in a community-dwelling population

Author(s): Sugawara N, Yasui-Furukori N, Umeda T, Kaneda A, Sato Y, et al.


Background:Vascular factors have been implicated in the development of cognitive decline and dementia. The purpose of this study is to determine the association of the Ankle Brachial pressure Index (ABI) and brachial-ankle Pulse Wave Velocity (ba-PWV) to cognitive impairment in a community-dwelling population.

Methods:The ABI and ba-PWV were measured using the volume-plethymographic apparatus in 388 subjects aged 60 years old and over. The Mini-Mental State Examination was also employed to measure global cognitive status. The effectiveness of the ABI and ba-PWV as putative markers of cognitive impairment were determined by using a multiple logistic regression analysis after adjusting for confounding factors.

Results:Subjects with poor cognition were significantly older and less well educated than those with normal cognition. According to the multiple logistic regression analysis, the lowest ABI tertile was found to be a significant independent risk factor (OR = 3.19, 95% CI = 1.30 to 7.82) of the cognitive impairment, whereas the highest brachial-ankle PWV tertile was not.

Conclusions:A low ABI was an independent risk factor for cognitive impairment in community-dwelling older populations, whereas a high ba-PWV may not be. Further research will be required to analyze ABI and PWV with greater accuracy.

Similar Articles

Ankle-brachial index as a marker of cognitive impairment and dementia in general population

Author(s): Guerchet M, Aboyans V, Nubukpo P, Lacroix P, Clément JP, et al.

Ankle-brachial index, cognitive impairment and cerebrovascular disease in a chinese population

Author(s): Hilal S, Saini M, Tan CS, Catindig JA, Dong YH, et al.

Pulse wave velocity is associated with β-amyloid deposition in the brains of very elderly adults

Author(s): Hughes TM, Kuller LH, Barinas-Mitchell EJ, Mackey RH, McDade EM, et al.

Aortic pulse wave velocity predicts focal white matter hyperintensities in a biracial cohort of older adults

Author(s): Rosano C, Watson N, Chang Y, Newman AB, Aizenstein HJ, et al.

Relations of arterial stiffness and endothelial function to brain aging in the community

Author(s): Tsao CW, Seshadri S, Beiser AS, Westwood AJ, Decarli C, et al.

Cerebral white matter lesions and atherosclerosis in the Rotterdam Study

Author(s): Bots ML, van Swieten JC, Breteler MM, de Jong PT, van Gijn J, et al.

Pathogenesis of leukoaraiosis: a review

Author(s): Pantoni L, Garcia JH

Increased aortic pulse wave velocity is associated with silent cerebral small-vessel disease in hypertensive patients

Author(s): Henskens LH, Kroon AA, van Oostenbrugge RJ, Gronenschild EH, Fuss-Lejeune MM, et al.

Threats to the mind: aging, amyloid, and hypertension

Author(s): Iadecola C, Park L, Capone C

Cerebral white matter lesions and cognitive function: the Rotterdam Scan Study

Author(s): de Groot JC, de Leeuw FE, Oudkerk M, van Gijn J, Hofman A, et al.