Author(s): Inglese M, Park SJ, Johnson G, Babb JS, Miles L, et al.
Objectives:To assess the presence of perfusion abnormalities in the deep gray matter of patients with relapsing-remitting and primary progressive multiple sclerosis (MS) in comparison with healthy controls and to investigate the impact of perfusion impairment on clinical disability and fatigue.
Setting:Research-oriented hospital. Patients Twenty-two patients with MS and 11 age- and sex-matched healthy volunteers. Intervention Absolute cerebral blood flow, cerebral blood volume, and mean transit time were measured in the thalamus, putamen, and caudate nuclei.
Main outcome measures:Decrease of cerebral blood flow in the deep gray matter of patients with MS and correlation between perfusion impairment and the severity of fatigue.
Results:The cerebral blood flow value averaged over the thalamus, putamen, and caudate nuclei was significantly lower in patients with primary progressive MS (P<.001) and in patients with relapsing-remitting MS (P = .01) compared with controls, and there was a trend for patients with primary progressive MS to have lower average cerebral blood flow than patients with relapsing-remitting MS (P = .06). With respect to cerebral blood volume, there was a significant difference between patients with primary progressive MS and controls (P<.001) and between the 2 groups of patients (P = .03) but not between patients with relapsing-remitting MS and controls (P>.30). The fatigue score was significantly correlated with cerebral blood flow (r = 0.4; P<.001) and cerebral blood volume (r = 0.5; P = .004).
Conclusion:The decrease of tissue perfusion in the deep gray matter of patients with MS is associated with the severity of fatigue.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/17296835
Author(s): Jung J, Morlet D, Mercier B, Confavreux C, Fischer C
Author(s): Slater JD, Wu FY, Honig LS, Ramsay RE, Morgan R
Author(s): Ellger T, Bethke F, Frese A, Luettmann RJ, Buchheister A, et al.
Author(s): Triantafyllou NI, Zalonis I, Kokotis P, Anthracopoulos M, Siafacas A, et al.
Author(s): Aminoff JC, Goodin DS
Author(s): Khedr EM, El Toony LF, Tarkhan MN, Abdella G
Author(s): Sunaga Y, Hikima A, Otsuka T, Nagashima K, Kuroume T
Author(s): Korpelainen JT, Kauhanen ML, Tolonen U, Brusin E, Mononen H, et al.
Author(s): Mochizuki Y, Oishi M, Takasu T
Author(s): Gerschlager W, Beisteiner R, Deecke L, Dirnberger G, Endl W, et al.
Author(s): Polich J, Ladish C, Bloom FE
Author(s): Gil R, Zai L, Neau JP, Jonveaux T, Agbo C, et al.
Author(s): Honig LS, Ramsay RE, Sheremata WA
Author(s): Triantafyllou NI, Voumvourakis K, Zalonis I, Sfagos K, Mantouvalos V, et al.
Author(s): Aaslid R, Markwalder TM, Nornes H
Author(s): Fodale V, Schifilliti D, Conti A, Lucanto T, Pino G, et al.
Author(s): Polman CH, Reingold SC, Banwell B, Clanet M, Cohen JA, et al.
Author(s): Kurtzke JF
Author(s): Bakshi R, Miletich RS, Kinkel PR, Emmet ML, Kinkel WR
Author(s): De Keyser J, Steen C, Mostert JP, Koch MW
Author(s): Ozkan S, Uzuner N, Kutlu C, Ozbabalik D, Ozdemir G
Author(s): Law M, Saindane AM, Ge Y, Babb JS, Johnson G, et al.
Author(s): Tachibana H, Toda K, Yokota N, Sugita M, Konishi K
Author(s): Yamashita K, Kobayashi S, Koide H, Okada K, Tsunematsu T
Author(s): Kuwata T, Funahashi K, Maeshima S, Ogura M, Hyotani G, et al.
Author(s): Jesus PA, Vieira-de-Melo RM, Reis FJ, Viana LC, Lacerda A, et al.
Author(s): Tiehuis AM, Vincken KL, van den Berg E, Hendrikse J, Manschot SM, et al.