Author(s): Burkhardt CR, Filley CM, Kleinschmidt-DeMasters BK, de la Monte S, Norenberg MD, et al.
Thirty cases of diffuse Lewy body disease (DLBD) have been reported, primarily by neuropathologists, but an associated clinical syndrome has not been clearly defined. Four recent cases have led us to examine the clinicopathologic correlations. Patients are usually elderly, with symptoms lasting from 1 to 20 years. Progressive dementia or psychosis is typically the first and most prominent feature. Parkinsonian signs, initially mild or absent, become common eventually, and rigidity is usually severe. Involuntary movements, myoclonus, quadriparesis in flexion, orthostatic hypotension, and dysphagia have also been noted. Classic, concentric Lewy bodies are found profusely in the brainstem, basal forebrain, and hypothalamic nuclei, while less well defined "Lewy-like" bodies occur in limbic structures and in deep neocortical layers. In addition, focal spongiform changes in the mesial temporal lobe were found in two of our cases. We suggest that DLBD may be another specific cause of progressive dementia.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/2843793
Author(s): Kosaka K, Yoshimura M, Ikeda K, Budka H
Author(s): Litvan I, MacIntyre A, Goetz CG, Wenning GK, Jellinger K, et al.
Author(s): Nelson PT, Jicha GA, Kryscio RJ, Abner EL, Schmitt FA, et al.
Author(s): Dickson DW
Author(s): Schneider JA, Arvanitakis Z, Yu L, Boyle PA, Leurgans SE, et al.
Author(s): Lippa CF, Duda JE, Grossman M, Hurtig HI, Aarsland D, et al.
Author(s): Hughes AJ, Daniel SE, Blankson S, Lees AJ
Author(s): Ransmayr G
Author(s): McKeith IG
Author(s): Hu WT, Watts K, Grossman M, Glass J, Lah JJ, et al.
Author(s): Cagnin A, Gnoato F, Jelcic N, Favaretto S, Zarantonello G, et al.
Author(s): Hamilton JM, Salmon DP, Galasko D, Raman R, Emond J, et al.
Author(s): Foster ER, Campbell MC, Burack MA, Hartlein J, Flores HP, et al.