Author(s): Trieu VN, Uckun FM
Amyotrophic lateral sclerosis (ALS), whether sporadic or familial (FALS), is a progressive, fatal neurodegenerative disorder involving the motor neurons of the cortex, brain stem, and spinal cord. In some studies, the male/female ratio of ALS patients was as high as 2 to 1. In FALS mice, disease onset and mortality were earlier among males than among females. This sexual dimorphism was due to estrogen, as treatment with genistein, a phytoestrogen, eliminated the observed sexual dimorphism in FALS mice. Genistein treatment also protected against oxygen singlet-induced cerebral damage in vivo. However, sexual dimorphism was not observed in this model of stroke; and genistein was equally effective in males and females. These data suggest that genistein has both estrogen-dependent and estrogen-independent neuroprotective activities and it should be investigated as a prophylactic agent against pathologic conditions such as ALS and stroke.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/10329446
Author(s): Du AL, Ji TL, Yang B, Cao JF, Zhang XG, et al.
Author(s): An J, Tzagarakis-Foster C, Scharschmidt TC, Lomri N, Leitman DC
Author(s): Jayakumar AR, Rao KV, Panickar KS, Moriyama M, Reddy PV, et al.
Author(s): Gibson CL, Gray LJ, Murphy SP, Bath PM
Author(s): Jover T, Tanaka H, Calderone A, Oguro K, Bennett MV, et al.
Author(s): Khaksari M, Soltani Z, Shahrokhi N, Moshtaghi G and Asadikaram G
Author(s): Shahrokhi N, Khaksari M, Soltani Z, Mahmoodi M, Nakhaee N
Author(s): Brass LM
Author(s): Wassertheil-Smoller S, Hendrix SL, Limacher M, Heiss G, Kooperberg C, et al.
Author(s): Cassidy A
Author(s): Michel T, Halabalaki M, Skaltsounis AL
Author(s): Rietjens IM, Sotoca AM, Vervoort J, Louisse J
Author(s): Paterni I, Granchi C1, Katzenellenbogen JA2, Minutolo F3
Author(s): Kronenberg F, Fugh-Berman A
Author(s): Lund TD, West TW, Tian LY, Bu LH, Simmons DL, et al.
Author(s): Bu L, Lephart ED
Author(s): Setchell KD
Author(s): Schreihofer DA, Do KD, Schreihofer AM
Author(s): Burguete MC, Torregrosa PA, Asensio G, Fernando J, CastellA, et al.
Author(s): Bourque M, Dluzen DE, Di Paolo T
Author(s): Chiang SS, Pan TM
Author(s): Newton KM, Buist DS, Keenan NL, Anderson LA, LaCroix AZ
Author(s): Lapchak PA, Zhang JH and Noble-Haeusslein LJ
Author(s): Khaksari M, Mahmmodi R, Shahrokhi N, Shabani M, Joukar S, et al.
Author(s): Asl SZ, Khaksari M, Khachki AS, Shahrokhi N, Nourizade S
Author(s): Consiglio AR, Lucion AB