Author(s): Suzuki H, Kanamaru K, Tsunoda H, Inada H, Kuroki M, et al.
Delayed cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH) causes cerebral ischemia and infarction. To date, the pathogenesis and gene expression associated with vasospasm remain poorly understood. The present study used fluorescent differential display to identify differentially expressed genes in a rat model of SAH. By using quantitative RT-PCR, we found that heme oxygenase-1 (HO-1) mRNA was prominently induced in the basilar artery and modestly in brain tissue in a rat vasospasm model. A significant correlation was observed between the degree of vasospasm and HO-1 mRNA levels in the basilar arteries exhibiting vasospasm. Intracisternal injection of antisense HO-1 oligodeoxynucleotide (ODN) significantly delayed the clearance of oxyhemoglobin and deoxyhemoglobin from the subarachnoid space and aggravated angiographic vasospasm. Antisense HO-1 ODN inhibited HO-1 induction in the basilar arteries but not in the whole brain tissue. This phenomenon was not observed in the nontreated, sense HO-1 ODN-treated, or scrambled ODN-treated arteries. We report the protective effects of HO-1 gene induction in cerebral vasospasm after SAH, a finding that should provide a novel therapeutic approach for cerebral vasospasm.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/10393699
Author(s): Kassell NF, Sasaki T, Colohan AR, Nazar G
Author(s): Stanton LW, Garrard LJ, Damm D, Garrick BL, Lam A, et al.
Author(s): Shi C, Awad IA, Jafari N, Lin S, Du P, et al.
Author(s): Pera J, Korostynski M, Krzyszkowski T, Czopek J, Slowik A, et al.
Author(s): Bolstad BM, Irizarry RA, Astrand M, Speed TP
Author(s): Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, et al.
Author(s): Saeed AI, Bhagabati NK, Braisted JC, Liang W, Sharov V, et al.
Author(s): Onda H, Kasuya H, Takakura K, Hori T, Imaizumi T, et al.
Author(s): Macdonald RL, Zhang ZD, Ono S, Komuro T
Author(s): Vikman P, Beg S, Khurana TS, Hansen-Schwartz J, Edvinsson L
Author(s): Sasahara A, Kasuya H, Krischek B, Tajima A, Onda H, et al.
Author(s): Kikkawa Y, Matsuo S, Kameda K, Hirano M, Nakamizo A, et al.
Author(s): Schwanhausser B, Busse D, Li N, Dittmar G, Schuchhardt J, et al.
Author(s): Borel CO, McKee A, Parra A, Haglund MM, Solan A, et al.
Author(s): Osuka K, Watanabe Y, Usuda N, Atsuzawa K, Wakabayashi T, et al.
Author(s): Yamaguchi-Okada M, Nishizawa S, Koide M, Nonaka Y
Author(s): Tang WH, Zhu G, Zhang JH, Chen Z, Liu Z, et al.
Author(s): Hughes JT, Schianchi PM
Author(s): Zhang J, Lewis A, Bernanke D, Zubkov A, Clower B
Author(s): Kim GH, Kellner CP, Hahn DK, Desantis BM, Musabbir M, et al.
Author(s): Zhou ML, Wu W, Ding YS, Zhang FF, Hang CH, et al.
Author(s): Wu Y, Tang K, Huang RQ, Zhuang Z, Cheng HL, et al.
Author(s): Suzuki H, Hasegawa Y, Kanamaru K, Zhang JH
Author(s): Meller R, Stevens SL, Minami M, Cameron JA, King S, et al.
Author(s): Xie Y, Sakatsume M, Nishi S, Narita I, Arakawa M, et al.
Author(s): Nagata K, Sasaki T, Mori T, Nikaido H, Kobayashi E, et al.
Author(s): Zubkov AY, Ogihara K, Bernanke DH, Parent AD, Zhang J
Author(s): Zhou C, Yamaguchi M, Colohan AR, Zhang JH
Author(s): Zubkov AY, Tibbs RE, Clower B, Ogihara K, Aoki K, et al.
Author(s): Sasaki T, Kassell NF, Yamashita M, Fujiwara S, Zuccarello M
Author(s): Sasaki T, Kassell NF, Zuccarello M, Nakagomi T, Fijiwara S, et al.
Author(s): Cahill J, Calvert JW, Solaroglu I, Zhang JH
Author(s): Sehba FA, Pluta RM, Zhang JH
Author(s): Ostergaard JR, Kristensen BO, Svehag SE, Teisner B, Miletic T
Author(s): Yanamoto H, Kikuchi H, Okamoto S, Nozaki K
