Author(s): Rezapour-Firouzi S, Arefhosseini SR, Mehdi F, Mehrangiz EM, Baradaran B, et al.
Background:Multiple sclerosis (MS) is the most chronic and inflammatory disorder. Because of limited efficacy and adverse side effects, identifying novel therapeutic and protective agents is important. This study was aimed to assess the potential therapeutic effects of hemp seed and evening primrose oils as well as Hot-nature dietary intervention on RRMS patients.
Methods and materials:In this double blind, randomized trial, 100 MS patients with EDSS<6 were allocated into 3 groups: "Group A" who received co-supplemented hemp seed and evening primrose oils with advised Hot-nature diet, "Group B" who received olive oil, "Group C" who received the co-supplemented oils. Mizadj, clinically EDSS and relapse rate as well as immunological factors (IL-4, IFN-γ and IL-17) were assessed at baseline and after 6 months.
Results:Mean follow-up was 180±2.9 SD days (N=65, 23 M and 42 F aged 34.25±8.07 years with disease duration 6.80±4.33 years). There was no significant difference in studies parameters at baseline. After 6 months, significant improvements in Mizadj, EDSS and relapse rate were found in the groups A and C, while the group B showed a border significant decrease in relapse rate. Immunological parameters showed improvement in groups A and C, whereas there was worsening condition for group B after the intervention.
Conclusion:The co-supplemented hemp seed and evening primrose oils with Hot-nature diet have beneficial effects in improving of clinical score in RRMS patients which were confirmed by immunological findings.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/24050582
Author(s): Hassan-Smith G, Douglas MR
Author(s): Río J, Comabella M, Montalban X
Author(s): Yadav V, Shinto L, Bourdette D
Author(s): Leong EM, Semple SJ, Angley M, Siebert W, Petkov J, et al.
Author(s): Marrie RA, Hadjimichael O, Vollmer T
Author(s): Schwarz S, Knorr C, Geiger H, Flachenecker P
Author(s): Shinto L, Calabrese C, Morris C, Yadav V, Griffith D, et al.
Author(s): vonGeldern G, Mowry EM
Author(s): Fetterman JW Jr, Zdanowicz MM
Author(s): Lands WE
Author(s): Calder PC
Author(s): Burdge GC, Calder PC
Author(s): Calder PC
Author(s): Yates CM, Calder PC, Ed Rainger G
Author(s): Gorjão R, Azevedo-Martins AK, Rodrigues HG, Abdulkader F, Arcisio-Miranda M, et al.
Author(s): Iwami D, Nonomura K, Shirasugi N, Niimi M
Author(s): Bates D, Cartlidge NE, French JM, Jackson MJ, Nightingale S, et al.
Author(s): Gallai V, Sarchielli P, Trequattrini A, Franceschini M, Floridi A, et al.
Author(s): Neu I, Mallinger J, Wildfeuer A, Mehlber L
Author(s): Weinstock-Guttman B, Baier M, Park Y, Feichter J, Lee-Kwen P, et al.
Author(s): Sierra S, Lara-Villoslada F, Comalada M, Olivares M, Xaus J
Author(s): Verlengia R, Gorjão R, Kanunfre CC, Bordin S, Martins De Lima T, et al.