Author(s): Hara T, Hirayama M, Mizutani Y, Hama T, Hori N, et al.
Background and purpose:Many non-motor symptoms are associated with Parkinson's disease (PD). Of these, pain and olfactory disturbance tend to be common premotor symptoms. PD has been shown to exhibit abnormal central pain processing, although underlying mechanisms are not yet fully understood. In order to investigate this further, we assessed PD patients by specific Aδ stimulation with intra-epidermal needle electrode and determined olfactory function.
Methods:Forty-two patients (18 males and 24 females) with PD and 17 healthy control subjects (8 males and 9 females) were studied. A thin needle electrode was used to stimulate epidermal Aδ fibers, and somatosensory evoked potentials (SEPs) recorded at the vertex. Olfactory function was evaluated using the Odor Stick Identification Test for Japanese (OSIT-J) and its relationship with pain-related SEPs was investigated.
Results:There were no significant differences in N1 latencies or P1 latencies although N1/P1 peak-to-peak amplitudes were significantly lower (p < 0.01) in PD patients than in control subjects. In PD patients, there were significant correlations between N1/P1 amplitudes and disease duration (r = -0.35, p < 0.05), Hoehn-Yahr stage (r = -0.38, p < 0.05) and UPDRS part III (r = -0.42, p < 0.01). Furthermore, the OSIT-J scores correlated with SEP amplitude (r = 0.41, p < 0.01).
Conclusion:Pain processing in PD patients was impaired under specific nociceptive stimulation of Aδ fibers and significant correlation with smell dysfunction was detected. We suggest that this mechanism may involve the limbic system during PD pathology.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/22818527
Author(s): Lee MA, Walker RW, Hildreth TJ, Prentice WM
Author(s): Bair MJ, Robinson RL, Katon W, Kroenke K
Author(s): McWilliams LA, Cox BJ, Enns MW
Author(s): Hanagasi HA, Akat S, Gurvit H, Yazici J, Emre M
Author(s): Nieoullon A
Author(s): Schneier FR, Liebowitz MR, Abi-Dargham A, Zea-Ponce Y, Lin SH, et al.
Author(s): Roh JH, Kim BJ, Jang JH, Seo WK, Lee SH, et al.
Author(s): Erro R, Santangelo G, Picillo M, Vitale C, Amboni M, et al.
Author(s): Hughes AJ, Daniel SE, Kilford L, Lees AJ
Author(s): Fahn S; Parkinson Study Group
Author(s): Nie K, Zhang Y, Wang L, Zhao J, Huang Z, et al.
Author(s): Chaudhuri KR, Martinez-Martin P, Schapira AH, Stocchi F, Sethi K, et al.
Author(s): Melzack R
Author(s): Cleeland CS, Ryan KM
Author(s): Smeding HM, Esselink RA, Schmand B, Koning-Haanstra M, Nijhuis I, et al.
Author(s): Ford B
Author(s): Airavaara M, Harvey BK, Voutilainen MH, Shen H, Chou J, et al.
Author(s): Ha AD, Jankovic J
Author(s): Santos-García D, Abella-Corral J, Aneiros-Díaz Á, Santos-Canelles H, Llaneza-González MA, et al.
Author(s): Yong MH, Allen JC Jr, Prakash KM, Tan EK
Author(s): Jarcho JM, Mayer EA, Jiang ZK, Feier NA, London ED
Author(s): Mylius V, Brebbermann J, Dohmann H, Engau I, Oertel WH, et al.
Author(s): Nutt JG
Author(s): Lim SY, Farrell MJ, Gibson SJ, Helme RD, Lang AE, et al.
Author(s): Romenets SR, Wolfson C, Galatas C, Pelletier A, Altman R, et al.
Author(s): Raudino F