Author(s): Jung J, Morlet D, Mercier B, Confavreux C, Fischer C
Methods:46 MS patients (mean age 43.7 years, mean disease duration 10.1 years, mean EDSS 4.6) and 46 matched controls were assessed with ERPs elicited by a passive oddball paradigm using duration deviants. Auditory P50, N1, P2 components were recorded. MMN and P3a components were calculated as the difference potential between deviants and standard stimuli. Eighteen of these 46 patients underwent also global psychometrical assessment and were sorted in cognitively normal and impaired patients. ERPs of these two groups of patients were compared.
Results:MS patients showed reduced MMN and P3a areas as compared to controls, besides exogenous N1-P2 complex amplitude reduction. Among the 18 patients investigated with neuropsychological testings, six were cognitively impaired and 12 cognitively unimpaired. Patients with a global cognitive impairment had reduced MMN as compared to cognitively unimpaired patients.
Conclusions:Auditory MMN and P3a components of auditory ERPs are altered in MS patients. MMN alterations are more pronounced in cognitively impaired patients.
Significance:MMN and P3a areas reduction suggests that MS patients are prone to pre-attentive auditory information processing deficits, besides previously described controlled information processing difficulties. Moreover, MMN alterations may represent an objective index of cognitive disturbances in MS patients.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/16325469
Author(s): Slater JD, Wu FY, Honig LS, Ramsay RE, Morgan R
Author(s): Ellger T, Bethke F, Frese A, Luettmann RJ, Buchheister A, et al.
Author(s): Triantafyllou NI, Zalonis I, Kokotis P, Anthracopoulos M, Siafacas A, et al.
Author(s): Aminoff JC, Goodin DS
Author(s): Khedr EM, El Toony LF, Tarkhan MN, Abdella G
Author(s): Sunaga Y, Hikima A, Otsuka T, Nagashima K, Kuroume T
Author(s): Korpelainen JT, Kauhanen ML, Tolonen U, Brusin E, Mononen H, et al.
Author(s): Mochizuki Y, Oishi M, Takasu T
Author(s): Gerschlager W, Beisteiner R, Deecke L, Dirnberger G, Endl W, et al.
Author(s): Polich J, Ladish C, Bloom FE
Author(s): Gil R, Zai L, Neau JP, Jonveaux T, Agbo C, et al.
Author(s): Honig LS, Ramsay RE, Sheremata WA
Author(s): Triantafyllou NI, Voumvourakis K, Zalonis I, Sfagos K, Mantouvalos V, et al.
Author(s): Aaslid R, Markwalder TM, Nornes H
Author(s): Fodale V, Schifilliti D, Conti A, Lucanto T, Pino G, et al.
Author(s): Polman CH, Reingold SC, Banwell B, Clanet M, Cohen JA, et al.
Author(s): Kurtzke JF
Author(s): Inglese M, Park SJ, Johnson G, Babb JS, Miles L, et al.
Author(s): Bakshi R, Miletich RS, Kinkel PR, Emmet ML, Kinkel WR
Author(s): De Keyser J, Steen C, Mostert JP, Koch MW
Author(s): Ozkan S, Uzuner N, Kutlu C, Ozbabalik D, Ozdemir G
Author(s): Law M, Saindane AM, Ge Y, Babb JS, Johnson G, et al.
Author(s): Tachibana H, Toda K, Yokota N, Sugita M, Konishi K
Author(s): Yamashita K, Kobayashi S, Koide H, Okada K, Tsunematsu T
Author(s): Kuwata T, Funahashi K, Maeshima S, Ogura M, Hyotani G, et al.
Author(s): Jesus PA, Vieira-de-Melo RM, Reis FJ, Viana LC, Lacerda A, et al.
Author(s): Tiehuis AM, Vincken KL, van den Berg E, Hendrikse J, Manschot SM, et al.