Author(s): Kim GH, Kellner CP, Hahn DK, Desantis BM, Musabbir M, et al.
Object:Despite efforts to elucidate both the molecular mechanism and the clinical predictors of vasospasm after aneurysmal subarachnoid hemorrhage (ASAH), its pathogenesis remains unclear. Monocyte chemoattractant protein-1 (MCP-1) is a chemokine that has been firmly implicated in the pathophysiology of vasospasm and in neural tissue injury following focal ischemia in both animal models and human studies. The authors hypothesized that MCP-1 would be found in increased concentrations in the blood and cerebrospinal fluid (CSF) of patients with ASAH and would correlate with both outcome and the occurrence of vasospasm.
Methods:Seventy-seven patients who presented with ASAH were prospectively enrolled in this study between July 2001 and May 2002. Using an enzyme-linked immunosorbent assay, MCP-1 levels were measured in serum daily and in CSF when available. The mean serum and CSF MCP-1 concentrations were calculated for each patient throughout the entire hospital stay. Neurological outcome was evaluated at discharge or 14 days posthemorrhage using the modified Rankin Scale. Vasospasm was evaluated on angiography.
Results:The serum MCP-1 concentrations correlated with negative outcome such that a 10% increase in concentration predicted a 25% increase in the probability of a poor outcome, whereas the serum MCP-1 levels did not correlate with vasospasm. Concentrations of MCP-1 in the CSF, however, proved to be significantly higher in patients with angiographically demonstrated vasospasm.
Conclusions:These findings suggest a role for MCP-1 in neurological injury and imply that it may act as a biomarker of poor outcome in the serum and of vasospasm in the CSF.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/18593272
Author(s): Kassell NF, Sasaki T, Colohan AR, Nazar G
Author(s): Stanton LW, Garrard LJ, Damm D, Garrick BL, Lam A, et al.
Author(s): Shi C, Awad IA, Jafari N, Lin S, Du P, et al.
Author(s): Pera J, Korostynski M, Krzyszkowski T, Czopek J, Slowik A, et al.
Author(s): Bolstad BM, Irizarry RA, Astrand M, Speed TP
Author(s): Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, et al.
Author(s): Saeed AI, Bhagabati NK, Braisted JC, Liang W, Sharov V, et al.
Author(s): Onda H, Kasuya H, Takakura K, Hori T, Imaizumi T, et al.
Author(s): Suzuki H, Kanamaru K, Tsunoda H, Inada H, Kuroki M, et al.
Author(s): Macdonald RL, Zhang ZD, Ono S, Komuro T
Author(s): Vikman P, Beg S, Khurana TS, Hansen-Schwartz J, Edvinsson L
Author(s): Sasahara A, Kasuya H, Krischek B, Tajima A, Onda H, et al.
Author(s): Kikkawa Y, Matsuo S, Kameda K, Hirano M, Nakamizo A, et al.
Author(s): Schwanhausser B, Busse D, Li N, Dittmar G, Schuchhardt J, et al.
Author(s): Borel CO, McKee A, Parra A, Haglund MM, Solan A, et al.
Author(s): Osuka K, Watanabe Y, Usuda N, Atsuzawa K, Wakabayashi T, et al.
Author(s): Yamaguchi-Okada M, Nishizawa S, Koide M, Nonaka Y
Author(s): Tang WH, Zhu G, Zhang JH, Chen Z, Liu Z, et al.
Author(s): Hughes JT, Schianchi PM
Author(s): Zhang J, Lewis A, Bernanke D, Zubkov A, Clower B
Author(s): Zhou ML, Wu W, Ding YS, Zhang FF, Hang CH, et al.
Author(s): Wu Y, Tang K, Huang RQ, Zhuang Z, Cheng HL, et al.
Author(s): Suzuki H, Hasegawa Y, Kanamaru K, Zhang JH
Author(s): Meller R, Stevens SL, Minami M, Cameron JA, King S, et al.
Author(s): Xie Y, Sakatsume M, Nishi S, Narita I, Arakawa M, et al.
Author(s): Nagata K, Sasaki T, Mori T, Nikaido H, Kobayashi E, et al.
Author(s): Zubkov AY, Ogihara K, Bernanke DH, Parent AD, Zhang J
Author(s): Zhou C, Yamaguchi M, Colohan AR, Zhang JH
Author(s): Zubkov AY, Tibbs RE, Clower B, Ogihara K, Aoki K, et al.
Author(s): Sasaki T, Kassell NF, Yamashita M, Fujiwara S, Zuccarello M
Author(s): Sasaki T, Kassell NF, Zuccarello M, Nakagomi T, Fijiwara S, et al.
Author(s): Cahill J, Calvert JW, Solaroglu I, Zhang JH
Author(s): Sehba FA, Pluta RM, Zhang JH
Author(s): Ostergaard JR, Kristensen BO, Svehag SE, Teisner B, Miletic T
Author(s): Yanamoto H, Kikuchi H, Okamoto S, Nozaki K
