Neutralizing antibodies to interleukin 1-receptor reduce pain associated behavior in mice with experimental neuropathy

Author(s): Sommer C, Petrausch S, Lindenlaub T, Toyka KV

Abstract

We investigated whether interleukin-1 (IL-1), a mediator of inflammatory pain, also plays a role in pain induced by nerve injury. Female C57BL/6-mice with a chronic constrictive injury of one sciatic nerve, an established model of neurogenic hyperalgesia and allodynia, were treated with different doses (10-80 microg) of a neutralizing monoclonal rat antibody to IL-1 receptor I (anti-IL-1RI). This antibody dose-dependently reduced thermal hyperalgesia and mechanical allodynia in the animals. Furthermore, immunoreactivity for the proinflammatory cytokine tumor necrosis factor-alpha (TNF) was reduced in mice treated with the highest dose of anti-IL-1RI. Degeneration of myelinated fibers was not altered by any of the treatment schedules. We conclude that IL-1 may be a mediator of hyperalgesia after nerve lesion.

Similar Articles

Sciatic nerve compression due to femoral neck osteochondroma: MDCT and MR findings

Author(s): TuranIlica A, Yasar E, Tuba Sanal H, Duran C, Guvenc I

A rare cause of non discal sciatica: schwannoma of the sciatic nerve

Author(s): Omezzine SJ, Zaara B, Ben Ali M, Abid F, Sassi N, et al.

Autotomy following peripheral nerve lesions: experimental anaesthesia dolorosa

Author(s): Wall PD, Devor M, Inbal R, Scadding JW, Schonfeld D, et al.

Assessment and analysis of mechanical allodynia-like behavior induced by spared nerve injury (SNI) in the mouse

Author(s): Bourquin AF, S├╝veges M, Pertin M, Gilliard N, Sardy S, et al.

A call for transparent reporting to optimize the predictive value of preclinical research

Author(s): Landis SC, Amara SG, Asadullah K, Austin CP, Blumenstein R, et al.

Differential effects of intravenous anaesthetic agents on cell-mediated immunity in the Rhesus monkey

Author(s): Thomas J, Carver M, Haisch C, Thomas F, Welch J, et al.