Author(s): Giladi N, Weitzman N, Schreiber S, Shabtai H, Peretz C
Alterations of impulse control that have recently been associated with Parkinson's disease (PD) are serious behavioural disturbances with significant impact on PD patients and their families.A total of 193 consecutive PD patients with no history of psychiatric illness and 190 age/gender-matched healthy controls were queried on the presence of new onset heightened interest or drive for gambling, shopping, eating or sexual activity (GSES). Clinical data were retrieved from medical charts and interviews. logistic regressions models assessed risk factors for these specific troublesome behaviours. New or heightened interests or drives for GSES behaviours were reported by 27 patients (14% vs 0% for controls). Younger age at PD motor symptoms onset (OR = 0.99, p = 0.0172), male gender (OR = 1.10, p = 0.0576) and longer duration of treatment with dopamine agonists (DAs)(OR = 1.18, >/=6 years versus never treated, p = 0.0459) contributed additively to the risk of developing one or more of these behavioural features. New onset heightened interests or drives for GSES are not rare behavioural disturbances among patients with PD. Age, gender and duration of treatment with DAs have an independent and additive effect on the risk to develop such behavioural changes. Patients should be informed about potential treatment-associated behavioural changes.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/17446202
Author(s): Pedersen KF, Larsen JP, Alves G, Aarsland D
Author(s): Pontone G, Williams JR, Bassett SS, Marsh L
Author(s): Leroi I, Ahearn DJ, Andrews M, McDonald KR, Byrne EJ, et al.
Author(s): Leroi I, Harbishettar V, Andrews M, McDonald K, Byrne EJ, et al.
Author(s): Robert PH, Clairet S, Benoit M, Koutaich J, Bertogliati C, et al.
Author(s): Weintraub D, Koester J, Potenza MN, Siderowf AD, Stacy M, et al.
Author(s): Kim YE, Jeon BS2
Author(s): Leroi I, Barraclough M, McKie S, Hinvest N, Evans J, et al.
Author(s): Mitaki S, Isomura M, Maniwa K, Yamasaki M, Nagai A, et al.
Author(s): Torta DM, Castelli L
Author(s): Lee JY, Seo SH, Kim YK, Yoo HB, Kim YE, et al.
Author(s): Lawrence AD, Brooks DJ, Whone AL
Author(s): Voon V, Sohr M, Lang AE, Potenza MN, Siderowf AD, et al.
Author(s): Evans AH, Lawrence AD, Potts J, Appel S, Lees AJ
Author(s): Weintraub D, Siderowf AD, Potenza MN, Goveas J, Morales KH, et al.
Author(s): Ondo WG, Lai D
Author(s): Voon V, Hassan K, Zurowski M, de Souza M, Thomsen T, et al.
Author(s): Weintraub D, Hoops S, Shea JA, Lyons KE, Pahwa R, et al.
Author(s): Ishihara L, Brayne C
Author(s): Arabia G, Grossardt BR, Colligan RC, Bower JH, Maraganore DM, et al.
Author(s): Gatto NM, Bordelon Y, Gatz M, Ritz B
Author(s): Ahearn DJ, McDonald K, Barraclough M, Leroi I
Author(s): Leroi I, Andrews M, McDonald K, Harbishettar V, Elliott R, et al.
Author(s): Emre M, Aarsland D, Brown R, Burn DJ, Duyckaerts C, et al.
Author(s): Starkstein SE, Mayberg HS, Preziosi TJ, Andrezejewski P, Leiguarda R, et al.
Author(s): Marin RS, Biedrzycki RC, Firinciogullari S
Author(s): Patton JH, Stanford MS, Barratt ES
Author(s): Zigmond AS, Snaith RP
Author(s): Tomilson CL, Stawe R, Patel S, Rick C, Gray R, et al.
Author(s): Benedetti MD, Bower JH, Maraganore DM, McDonnell SK, Peterson BJ, et al.
Author(s): Dagher A, Robbins TW
Author(s): Cloninger CR
Author(s): Roiser JP, Cook LJ, Cooper JD, Rubinsztein DC, Sahakian BJ
Author(s): Jacobs H, Heberlein I, Vieregge A, Vieregge P
Author(s): Archer N, Brown RG, Reeves SJ, Boothby H, Nicholas H, et al.