Author(s): Ikemoto K, Nishimura A, Oda T, Nagatsu I, Nishi K
The human striatum, especially its ventral part, the nucleus accumbens, contains numerous neurons immunoreactive for aromatic L-amino acid decarboxylase (AADC, the second-step monoamine synthesizing enzyme, =DDC: dopa decarboxylase), but not for tyrosine hydroxylase (TH, the first-step catecholamine synthesizing enzyme) or tryptophan hydroxylase (TPH, the first-step serotonin synthesizing enzyme) (Neurosci Lett 232 (1997) 111-114). These AADC (+)/TH (-)/TPH (-) neurons are named as D-neurons (Jaeger CB, Ruggiero DA, Albert VR, Joh TH, Reis DJ. Immunocytochemical localization of aromatic-L-amino acid decarboxylase. In: Bjorklund A, Hokfelt T, editors. Classical transmission in the CNS, Part I, Handbook of chemical neuroanatomy, vol. 2. Amsterdam: Elsevier, 1984. pp. 387-418). The nucleus accumbens is one of the brain regions that is involved in the pathogenesis of schizophrenia. We examined the distribution of striatal D-neurons using AADC immunohistochemistry and postmortem brains obtained by legal and pathological autopsies (nine controls (27-75 years old) and nine schizophrenics (32-78 years old), postmortem interval to fixation (PMI): 2-30 h). Because the number of AADC-positive neurons per section had a tendency to reduce in the case with longer PMI, we analyzed specimens of five controls (27-64 years old) and six schizophrenics (51-78 years old) in which the PMI was less than 8 h. The number of AADC-positive neurons was reduced in the striatum of schizophrenics compared to that of controls. The reduction was significant in the nucleus accumbens (P<0.05, t-test). D-Neurons might be involved in the pathogenesis of schizophrenia. Further studies using sex-, age- and PMI-matched controls are essential.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/12935595
Author(s): Hökfelt T, Ljungdahl A, Fuxe K, Johansson O
Author(s): Toru M, Nishikawa T, Mataga N, Takashima M
Author(s): Watis L, Chen SH, Chua HC, Chong SA, Sim K
Author(s): Olbrich HM, Valerius G, Rüsch N, Buchert M, Thiel T, et al.
Author(s): Christison GW, Casanova MF, Weinberger DR, Rawlings R, Kleinman JE
Author(s): McGlashan TH, Hoffman RE
Author(s): Duan X, Chang JH, Ge S, Faulkner RL, Kim JY, et al.
Author(s): Reif A, Fritzen S, Finger M, Strobel A, Lauer M, et al.
Author(s): Jaeger CB, Teitelman G, Joh TH, Albert VR, Park DH, et al.
Author(s): Boulton AA, Juorio AV
Author(s): Jaeger CB, Ruggiero DA, Albert VR, Park DH, Joh TH, et al.
Author(s): Tashiro Y, Kaneko T, Sugimoto T, Nagatsu I, Kikuchi H, et al.
Author(s): Mura A, Linder JC, Young SJ, Groves PM
Author(s): Ikemoto K, Kitahama K, Jouvet A, Arai R, Nishimura A, et al.
Author(s): Ikemoto K, Nagatsu I, Kitahama K, Jouvet A, Nishimura A, et al.
Author(s): Kitahama K, Ikemoto K, Jouvet A, Nagatsu I, Sakamoto N, et al.
Author(s): Kitahama K, Ikemoto K, Jouvet A, Araneda S, Nagatsu I, et al.
Author(s): Ikemoto K
Author(s): Bunzow JR, Sonders MS, Arttamangkul S, Harrison LM, Zhang G, et al.
Author(s): Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, et al.
Author(s): Miller GM
Author(s): Xie Z, Miller GM
Author(s): Xie Z, Miller GM
Author(s): Lindemann L, Meyer CA, Jeanneau K, Bradaia A, Ozmen L, et al.
Author(s): Zucchi R, Chiellini G, Scanlan TS, Grandy DK
Author(s): Bradaia A, Trube G, Stalder H, Norcross RD, Ozmen L, et al.