Author(s): Furio AM, Brusco LI, Cardinali DP
Mild cognitive impairment (MCI) is an etiologically heterogeneous syndrome characterized by cognitive impairment preceding dementia. Approximately 12% of MCI patients convert to Alzheimer's disease (AD) or other dementia disorders every year. In the present report we retrospectively examined the initial and final neuropsychological assessment of 50 MCI outpatients, 25 of whom had received daily 3-9 mg of a fast-release melatonin preparation p.o. at bedtime for 9-18 months. Melatonin was given in addition to the standard medication prescribed by the attending psychiatrist. Patients treated with melatonin showed significantly better performance in Mini Mental State Examination and the cognitive subscale of the Alzheimer's Disease Assessment Scale. After application of a battery of neuropsychological tests including Mattis' test, Digit-symbol test, Trail A and B tasks and the Rey's verbal test, better performance was found in melatonin-treated patients, except for the Digit-symbol test score which remained unchanged. Abnormally high Beck Depression Inventory scores decreased in melatonin-treated patients, concomitantly with an improvement in wakefulness and sleep quality. The results suggest that melatonin can be a useful add-on drug for treating MCI in a clinical setting.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/17910609
Author(s): Budson AE, Solomon PR
Author(s): Goate A, Chartier-Harlin MC, Mullan M, Brown J, Crawford F, et al.
Author(s): Mullan M, Crawford F, Axelman K, Houlden H, Lilius L, et al.
Author(s): Cruts M, Hendriks L, Van Broeckhoven C
Author(s): Strittmatter WJ, Roses AD
Author(s): Leoni V
Author(s): Bell RD, Winkler EA, Singh I, Sagare AP, Deane R, et al.
Author(s): Liu RY, Zhou JN, van Heerikhuize J, Hofman MA, Swaab DF
Author(s): Wu YH, Feenstra MG, Zhou JN, Liu RY, Toranõ JS, et al.
Author(s): Quera Salva MA, Hartley S, Barbot F, Alvarez JC, Lofaso F, et al.
Author(s): Reiter RJ, Manchester LC, Tan DX
Author(s): Liu R, Fu A, Hoffman AE, Zheng T, Zhu Y
Author(s): He H, Dong W, Huang F
Author(s): Haass C, Selkoe DJ
Author(s): Yasojima K, Mc Geer EG, Mc Geer PL
Author(s): Alvarez A, Alarcón R, Opazo C, Campos EO, Muñoz FJ, et al.
Author(s): Iwata N, Tsubuki S, Takaki Y, Watanabe K, Sekiguchi M, et al.
Author(s): Bush AI, Tanzi RE
Author(s): Craddock TJ, Tuszynski JA, Chopra D, Casey N, Goldstein LE, et al.
Author(s): Alonso A, Zaidi T, Novak M, Grundke-Iqbal I, Iqbal K
Author(s): Quinn J, Kulhanek D, Nowlin J, Jones R, Praticò D, et al.
Author(s): Cardinali DP, Furio AM, Brusco LI
Author(s): McCurry SM, Reynolds CF, Ancoli-Israel S, Teri L, Vitiello MV
Author(s): Brusco LI, Márquez M, Cardinali DP
Author(s): Khachiyants N, Trinkle D, Son SJ, Kim KY
Author(s): Jean-Louis G, von Gizycki H, Zizi F
Author(s): Rondanelli M, Opizzi A, Faliva M, Mozzoni M, Antoniello N, et al.