Prognosis of transient ischemic attacks in the Oxfordshire Community Stroke Project

Author(s): Dennis M, Bamford J, Sandercock P, Warlow C


In a community-based study of approximately 105,000 people, 184 presented with a transient ischemic attack during the 5 years between 1981 and 1986; we believe these persons represent almost all new cases of transient ischemic attack going to a doctor during that period. During a mean follow-up of 3.7 years 49 patients died, 45 had a first-ever stroke, and 17 had a myocardial infarction. Cardiac disease accounted for 17 (35%) deaths, while stroke was the cause of death in 15 patients (31%). The average actuarial risk of death was approximately 6.3%/yr, slightly greater than that expected for similar people without transient ischemic attacks (risk ratio [observed divided by expected] = 1.4). The actuarial risk of stroke was 11.6% during the first year after a transient ischemic attack and approximately 5.9%/yr over the first 5 years. Patients who suffered a transient ischemic attack had a 13-fold excess risk of stroke during the first year and a sevenfold excess risk over the first 7 years compared with people without transient ischemic attacks. The actuarial risk of death, stroke, or myocardial infarction over the first 5 years after a transient ischemic attack was approximately 8.4%/yr. The prognosis in this community-based cohort was better than that in previous reports. The high early risk of stroke means that investigation and treatment of new cases should commence as soon as possible.

Similar Articles

Short-term prognosis after emergency department diagnosis of TIA

Author(s): Johnston SC, Gress DR, Browner WS, Sidney S

Transient ischemic attacks in rural and urban northern Portugal: incidence and short-term prognosis

Author(s): Correia M, Silva MR, Magalhães R, Guimarães L, Silva MC

Stroke-unit care for acute stroke patients: an observational follow-up study

Author(s): Candelise L, Gattinoni M, Bersano A, Micieli G, Sterzi R, et al.

National Stroke Association guidelines for the management of transient ischemic attacks

Author(s): Johnston SC, Nguyen-Huynh MN, Schwarz ME, Fuller K, Williams CE, et al.

Guidelines for management of ischaemic stroke and transient ischaemic attack 2008

Author(s): European Stroke Organisation (ESO) Executive Committee; ESO Writing Committee

Diagnosis of transient ischemic attack by the nonneurologist

Author(s): Ferro JM, Falcão I, Rodrigues G, Canhão P, Melo TP, et al.

A prospective cohort study of patients with transient ischemic attack to identify high-risk clinical characteristics

Author(s): Perry JJ, Sharma M, Sivilotti ML, Sutherland J, Worster A, et al.

TIA triage in emergency department using acute MRI (TIA-TEAM): A feasibility and safety study

Author(s): Vora N, Tung CE, Mlynash M, Garcia M, Kemp S, et al.

In-hospital initiation of secondary stroke prevention therapies yields high rates of adherence at follow-up

Author(s): Ovbiagele B, Saver JL, Fredieu A, Suzuki S, Selco S, et al.

Trends over time in the risk of stroke after an incident transient ischemic attack

Author(s): Sundararajan V, Thrift AG, Phan TG, Choi PM, Clissold B, et al.