Quantitative brain MRI lesion load predicts the course of clinically isolated syndromes suggestive of multiple sclerosis

Author(s): Filippi M, Horsfield MA, Morrissey SP, MacManus DG, Rudge P, et al.


We performed semiautomated quantitative measurement of brain magnetic resonance imaging (MRI) abnormalities seen at presentation and at 5-year follow-up in 84 patients presenting with an acute clinically isolated syndrome of the optic nerves, brainstem, or spinal cord suggestive of multiple sclerosis (MS). At follow-up, 34 (40%) had developed clinically definite and four (5%) clinically probable MS. Patients who developed MS during follow-up had a higher lesion load at presentation than those who did not. There was a strong correlation of the MRI lesion load at presentation with both the increase in lesion load over the next 5 years and disability at follow-up. Increasing initial lesion load correlated with a decreasing time to development of MS clinically (r = -0.328, p < 0.05). At follow-up, disability and brain lesion load were strongly correlated in patients who had developed MS. These results establish that MRI at presentation with clinically isolated syndromes suggestive of MS is useful in predicting the subsequent clinical course and the development of new MRI lesions. This suggests that quantitative brain MRI will be helpful in selecting patients with early clinical MS for treatment trials and for subsequent monitoring of their response to treatment.

Similar Articles

Intramuscular interferon beta-1a therapy initiated during a first demyelinating event in multiple sclerosis

Author(s): Jacobs LD, Beck RW, Simon JH, Kinkel RP, Brownscheidle CM et al.

Quality of life in multiple sclerosis patients in Spain

Author(s): Chang CH, Cella D, Fernández O, Luque G, de Castro P, et al.

[The Spanish version of EuroQol: a description and its applications

Author(s): Badia X, Roset M, Montserrat S, Herdman M, Segura A

Autonomous regulation and long-term medication adherence in adult outpatients

Author(s): Williams GC, Rodin GC, Ryan RM, Grolnick WS, Deci EL

Pregnancy outcomes during treatment with interferon beta-1a in patients with multiple sclerosis

Author(s): Sandberg-Wollheim M, Frank D, Goodwin TM, Giesser B, Lopez-Bresnahan M, et al.