Author(s): Filippi M, Horsfield MA, Morrissey SP, MacManus DG, Rudge P, et al.
We performed semiautomated quantitative measurement of brain magnetic resonance imaging (MRI) abnormalities seen at presentation and at 5-year follow-up in 84 patients presenting with an acute clinically isolated syndrome of the optic nerves, brainstem, or spinal cord suggestive of multiple sclerosis (MS). At follow-up, 34 (40%) had developed clinically definite and four (5%) clinically probable MS. Patients who developed MS during follow-up had a higher lesion load at presentation than those who did not. There was a strong correlation of the MRI lesion load at presentation with both the increase in lesion load over the next 5 years and disability at follow-up. Increasing initial lesion load correlated with a decreasing time to development of MS clinically (r = -0.328, p < 0.05). At follow-up, disability and brain lesion load were strongly correlated in patients who had developed MS. These results establish that MRI at presentation with clinically isolated syndromes suggestive of MS is useful in predicting the subsequent clinical course and the development of new MRI lesions. This suggests that quantitative brain MRI will be helpful in selecting patients with early clinical MS for treatment trials and for subsequent monitoring of their response to treatment.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/8164816
Author(s): Kappos L, Moeri D, Radue EW, Schoetzau A, Schweikert K, et al.
Author(s): Jacobs LD, Beck RW, Simon JH, Kinkel RP, Brownscheidle CM et al.
Author(s): Chang CH, Cella D, Fernández O, Luque G, de Castro P, et al.
Author(s): Badia X, Roset M, Montserrat S, Herdman M, Segura A
Author(s): Tintoré M
Author(s): Comi G, Martinelli V, Rodegher M, Moiola L, Bajenaru O, et al.
Author(s): Kappos L, Polman CH, Freedman MS, Edan G, Hartung HP, et al.
Author(s): Comi G, De Stefano N, Freedman MS, Barkhof F, Polman CH, et al.
Author(s): Kinkel RP, Dontchev M, Kollman C, Skaramagas TT, O’Connor PW, et al.
Author(s): Miller D, Barkhof F, Montalban X, Thompson A, Filippi M
Author(s): Williams GC, Rodin GC, Ryan RM, Grolnick WS, Deci EL
Author(s): Nortvedt MW, Riise T, Myhr KM, Nyland HI
Author(s): Rudick RA, Miller DM
Author(s): Kappos L, Freedman MS, Polman CH, Edan G, Hartung H-P, et al.
Author(s): Zivadinov R, Zorzon M, Tommasi MA, Nasuelli D, Bernardi M, et al.
Author(s): Sandberg-Wollheim M, Frank D, Goodwin TM, Giesser B, Lopez-Bresnahan M, et al.