Author(s): Kako E, Kaneko N, Aoyama M, Hida H, Takebayashi H, et al.
Perinatal hypoxia-ischemia (HI) frequently causes white-matter injury, leading to severe neurological deficits and mortality, and only limited therapeutic options exist. The white matter of animal models and human patients with HI-induced brain injury contains increased numbers of oligodendrocyte progenitor cells (OPCs). However, the origin and fates of these OPCs and their potential to repair injured white matter remain unclear. Here, using cell-type- and region-specific genetic labeling methods in a mouse HI model, we characterized the Olig2-expressing OPCs. We found that after HI, Olig2+ cells increased in the posterior part of the subventricular zone (pSVZ) and migrated into the injured white matter. However, their oligodendrocytic differentiation efficiency was severely compromised compared with the OPCs in normal tissue, indicating the need for an intervention to promote their differentiation. Erythropoietin (EPO) treatment is a promising candidate, but it has detrimental effects that preclude its clinical use for brain injury. We found that long-term postinjury treatment with a nonerythropoietic derivative of EPO, asialo-erythropoietin, promoted the maturation of pSVZ-derived OPCs and the recovery of neurological function, without affecting hematopoiesis. These results demonstrate the limitation and potential of endogenous OPCs in the pSVZ as a therapeutic target for treating neonatal white-matter injury.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/22890889
Author(s): Hung CW, Liou YJ, Lu SW, Tseng LM, Kao CL, et al.
Author(s): Leker RR, McKay RD
Author(s): Nakaguchi K, Masuda H, Kaneko N, Sawamoto K
Author(s): Kaneko Y, Tajiri N, Shinozuka K, Glover LE, Weinbren NL, et al.
Author(s): Uemura M, Kasahara Y, Nagatsuka K, Taguchi A
Author(s): Gage FH
Author(s): Doetsch F, Caillé I, Lim DA, García-Verdugo JM, Alvarez-Buylla A
Author(s): Iwai M, Sato K, Omori N, Nagano I, Manabe Y, et al.
Author(s): Iwai M, Sato K, Kamada H, Omori N, Nagano I, et al.
Author(s): Arvidsson A, Collin T, Kirik D, Kokaia Z, Lindvall O
Author(s): Teramoto T, Qiu J, Plumier JC, Moskowitz MA
Author(s): Gensert JM, Goldman JE
Author(s): Menn B, Garcia-Verdugo JM, Yaschine C, Gonzalez-Perez O, Rowitch D, et al.
Author(s): Ninomiya M, Yamashita T, Araki N, Okano H, Sawamoto K
Author(s): Türeyen K, Vemuganti R, Bowen KK, Sailor KA, Dempsey RJ
Author(s): Emsley JG, Hagg T
Author(s): Yan YP, Sailor KA, Vemuganti R, Dempsey RJ
Author(s): Zhu W, Cheng S, Xu G, Ma M, Zhou Z, et al.
Author(s): Zhang ZG, Zhang L, Jiang Q, Zhang R, Davies K, et al.
Author(s): Hess DC, Hill WD, Martin-Studdard A, Carroll J, Brailer J, et al.
Author(s): Paczkowska E, Kucia M, Koziarska D, Halasa M, Safranow K, et al.
Author(s): Beltrami AP, Barlucchi L, Torella D, Baker M, Limana F, et al.
Author(s): Asahara T, Takahashi T, Masuda H, Kalka C, Chen D, et al.
Author(s): Kalka C, Masuda H, Takahashi T, Gordon R, Tepper O, et al.
Author(s): Sehara Y, Hayashi T, Deguchi K, Zhang H, Tsuchiya A, et al.