Author(s): Venda LL, Cragg SJ, Buchman VL, Wade-Martins R
α-Synuclein is central to the Lewy body neuropathology of Parkinson's disease (PD), a devastating neurodegenerative disorder characterized by numerous motor and non-motor manifestations. The cardinal motor symptoms are linked to death of dopaminergic neurons in the nigrostriatal pathway. Here we ask why these neurons are preferentially susceptible to neurodegeneration in PD and how α-synuclein is involved. To address these questions we bring together recent findings from genome-wide association studies, which reveal the involvement of α-synuclein gene variants in sporadic PD, with recent studies highlighting important roles for α-synuclein in synaptic transmission and dopaminergic neuron physiology. These latest advances add to our understanding of PD etiology and provide a central link between the genetic findings and neurodegeneration observed in sporadic PD.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/20961626
Author(s): Reynolds AD, Banerjee R, Liu J, Gendelman HE, Mosley RL
Author(s): Brochard V, Combadière B, Prigent A, Laouar Y, Perrin A, et al.
Author(s): McGeer PL, Itagaki S, Boyes BE, McGeer EG
Author(s): Mogi M, Harada M, Narabayashi H, Inagaki H, Minami M, et al.
Author(s): Baba Y, Kuroiwa A, Uitti RJ, Wszolek ZK, Yamada T
Author(s): Bas J, Calopa M, Mestre M, Molleví DG, Cutillas B, et al.
Author(s): Calopa M, Bas J, Callén A, Mestre M
Author(s): Reynolds AD, Stone DK, Mosley RL, Gendelman HE
Author(s): Laurie C, Reynolds A, Coskun O, Bowman E, Gendelman HE, et al.
Author(s): Dutheil F, Jacob A, Dauchy S, Beaune P, Scherrmann JM, et al.
Author(s): Mahringer A, Ott M, Reimold I, Reichel V, Fricker G
Author(s): van Vliet EA, van Schaik R, Edelbroek PM, Voskuyl RA, Redeker S, et al.
Author(s): van Vliet EA, da Costa Araújo S, Redeker S, van Schaik R, Aronica E, et al.
Author(s): Minagar A, Alexander JS
Author(s): Chung YC, Ko HW, Bok E, Park ES, Huh SH, et al.
Author(s): Chen X, Ghribi O, Geiger JD
Author(s): Huang R, Ke W, Liu Y, Wu D, Feng L, et al.
Author(s): Vautier S, Milane A, Fernandez C, Chacun H, Lacomblez L, et al.
Author(s): Vautier S, Fernandez C
Author(s): Bartels AL, Kortekaas R, Bart J, Willemsen AT, de Klerk OL et al,
Author(s): Bartels AL, Willemsen AT, Kortekaas R, de Jong BM, de Vries R, et al.
Author(s): Henry V, Paillé V, Lelan F, Brachet P, Damier P
Author(s): Olsson M,Nikkhah G, Bentlage C, Björklund A
Author(s): Kirik D,Rosenblad C andBjorklund A
Author(s): Schallert T, Fleming SM, Leasure JL, Tillerson JL, Bland ST
Author(s): Lundblad M, Andersson M, Winkler C, Kirik D, Wierup N, et al.
Author(s): Koronyo-Hamaoui M, Ko MK, Koronyo Y, Azoulay D, Seksenyan A, et al.
Author(s): Chang JY, Shi LH, Luo F, Woodward DJ
Author(s): Rozas G, Guerra MJ, Labandeira-García JL
Author(s): Reynolds AD, Stone DK, Hutter JA, Benner EJ, Mosley RL, et al.
Author(s): Reynolds AD, Stone DK, Mosley RL, Gendelman HE
Author(s): Depboylu C, Stricker S, Ghobril JP, Oertel WH, Priller J, et al.
Author(s): Fiszer U, Michałowska M, Baranowska B, Wolińska-Witort E, Jeske W, et al.
Author(s): Stone DK, Reynolds AD, Mosley RL, Gendelman HE
Author(s): Moalem G, Monsonego A, Shani Y, Cohen IR, Schwartz M
Author(s): Gruden MA, Sewell RD, Yanamandra K, Davidova TV, Kucheryanu VG, et al.
Author(s): Double KL, Rowe DB, Carew-Jones FM, Hayes M, Chan DK, et al.
Author(s): Bakay RA, Boyer KL, Freed CR, Ansari AA
Author(s): Masliah E, Rockenstein E, Adame A, Alford M, Crews L, et al.
Author(s): Johnston LC, Su X, Maguire-Zeiss K, Horovitz K, Ankoudinova I, et al.
Author(s): Oueslati A, Fournier M, Lashuel HA
Author(s): Desai BS, Monahan AJ, Carvey PM, Hendey B
Author(s): Boka G, Anglade P, Wallach D, Javoy-Agid F, Agid Y, et al.
Author(s): Hunot S, Dugas N, Faucheux B, Hartmann A, Tardieu M, et al.
Author(s): Town T, Nikolic V, Tan J
Author(s): Town T, Tan J, Flavell RA, Mullan M
Author(s): Kim JB, Sig Choi J, Yu YM, Nam K, Piao CS, et al.
