Author(s): Debette S, Markus HS
Objectives:To review the evidence for an association of white matter hyperintensities with risk of stroke, cognitive decline, dementia, and death.
Design:Systematic review and meta-analysis.
Data sources:PubMed from 1966 to 23 November 2009.
Study selection:Prospective longitudinal studies that used magnetic resonance imaging and assessed the impact of white matter hyperintensities on risk of incident stroke, cognitive decline, dementia, and death, and, for the meta-analysis, studies that provided risk estimates for a categorical measure of white matter hyperintensities, assessing the impact of these lesions on risk of stroke, dementia, and death.
Data extraction:Population studied, duration of follow-up, method used to measure white matter hyperintensities, definition of the outcome, and measure of the association of white matter hyperintensities with the outcome.
Data synthesis:46 longitudinal studies evaluated the association of white matter hyperintensities with risk of stroke (n=12), cognitive decline (n=19), dementia (n=17), and death (n=10). 22 studies could be included in a meta-analysis (nine of stroke, nine of dementia, eight of death). White matter hyperintensities were associated with an increased risk of stroke (hazard ratio 3.3, 95% confidence interval 2.6 to 4.4), dementia (1.9, 1.3 to 2.8), and death (2.0, 1.6 to 2.7). An association of white matter hyperintensities with a faster decline in global cognitive performance, executive function, and processing speed was also suggested.
Conclusion:White matter hyperintensities predict an increased risk of stroke, dementia, and death. Therefore white matter hyperintensities indicate an increased risk of cerebrovascular events when identified as part of diagnostic investigations, and support their use as an intermediate marker in a research setting. Their discovery should prompt detailed screening for risk factors of stroke and dementia.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/20660506
Author(s): Gorelick PB, Scuteri A, Black SE, Decarli C, Greenberg SM, et al.
Author(s): Guerchet M, Aboyans V, Nubukpo P, Lacroix P, Clément JP, et al.
Author(s): Hanon O, Haulon S, Lenoir H, Seux ML, Rigaud AS, et al.
Author(s): Hilal S, Saini M, Tan CS, Catindig JA, Dong YH, et al.
Author(s): Price JF, McDowell S, Whiteman MC, Deary IJ, Stewart MC, et al.
Author(s): Sugawara N, Yasui-Furukori N, Umeda T, Kaneda A, Sato Y, et al.
Author(s): Caruana MF, Bradbury AW, Adam DJ.
Author(s): Drouet L
Author(s): Henry-Feugeas MC
Author(s): Brandts A, van Elderen SG, Westenberg JJ, van der Grond J, van Buchem MA, et al.
Author(s): Hughes TM, Kuller LH, Barinas-Mitchell EJ, Mackey RH, McDade EM, et al.
Author(s): King KS, Chen KX, Hulsey KM, McColl RW, Weiner MF, et al.
Author(s): Kuo HK, Chen CY, Liu HM, Yen CJ, Chang KJ, et al.
Author(s): Rosano C, Watson N, Chang Y, Newman AB, Aizenstein HJ, et al.
Author(s): Saji N, Kimura K, Shimizu H, Kita Y
Author(s): Saji N, Shimizu H, Kawarai T, Tadano M, Kita Y, et al.
Author(s): Tsao CW, Seshadri S, Beiser AS, Westwood AJ, Decarli C, et al.
Author(s): Bots ML, van Swieten JC, Breteler MM, de Jong PT, van Gijn J, et al.
Author(s): Ovbiagele B, Saver JL
Author(s): Pantoni L, Garcia JH
Author(s): Au R, Massaro JM, Wolf PA, Young ME, Beiser A, et al.
Author(s): Provenzano FA, Muraskin J, Tosto G, Narkhede A, Wasserman BT, et al.
Author(s): Henskens LH, Kroon AA, van Oostenbrugge RJ, Gronenschild EH, Fuss-Lejeune MM, et al.
Author(s): Mitchell GF
Author(s): Iadecola C, Park L, Capone C
Author(s): de Groot JC, de Leeuw FE, Oudkerk M, van Gijn J, Hofman A, et al.
