The relationship of pain and health-related quality of life in Korean patients with Parkinson's disease

Author(s): Roh JH, Kim BJ, Jang JH, Seo WK, Lee SH, et al.


Background:Parkinson's disease (PD) is a chronic progressive neurodegenerative disorder. Increasing attention has been focused on the pain and health-related quality of life (HrQOL) in patients with PD. Objective - To evaluate the relationship between pain and the HrQOL in patients with PD.

Methods:Eighty-two patients with PD were included and classified into two groups according to the presence of pain. The Hoehn and Yahr scale, the Unified Parkinson's Disease Rating Scale (UPDRS), the Modified Somatic Perception Questionnaire (MSPQ), the Zung Depression Inventory--Self-rating Depression Scale (SDS), the Visual Analogue Scale and the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36) were administered. The factors influencing the pain, HrQOL and parkinsonian manifestations were evaluated.

Results:The PD with pain group had higher UPDRS part III scores, lower SF-36 scores, higher SDS scores and higher MSPQ scores than the PD without pain group. The presence of pain, high Hoehn and Yahr stage, advanced age and somatic perception were the factors that had a negative effect on the physical component of the HrQOL. Depression and somatic perception were the most important predictive factors for the mental component of the HrQOL. Depression and poor parkinsonian motor abilities were the leading factors contributing to pain.

Conclusion:Pain and depression were major detrimental factors affecting the physical and mental aspects of the HrQOL respectively. Therefore, the treatment of pain and depression can be important to improve the HrQOL.

Similar Articles

A survey of pain in idiopathic Parkinson's disease

Author(s): Lee MA, Walker RW, Hildreth TJ, Prentice WM

Depression and pain comorbidity: a literature review

Author(s): Bair MJ, Robinson RL, Katon W, Kroenke K

Pain is common in Parkinson's disease

Author(s): Hanagasi HA, Akat S, Gurvit H, Yazici J, Emre M

Low dopamine D(2) receptor binding potential in social phobia

Author(s): Schneier FR, Liebowitz MR, Abi-Dargham A, Zea-Ponce Y, Lin SH, et al.

Link between non-motor symptoms and cognitive dysfunctions in de novo, drug-naive PD patients

Author(s): Erro R, Santangelo G, Picillo M, Vitale C, Amboni M, et al.

Unilateral pallidotomy versus bilateral subthalamic nucleus stimulation in PD--a comparison of neuropsychological effects

Author(s): Smeding HM, Esselink RA, Schmand B, Koning-Haanstra M, Nijhuis I, et al.

Pain in Parkinson's disease

Author(s): Ford B

CDNF protects the nigrostriatal dopamine system and promotes recovery after MPTP treatment in mice

Author(s): Airavaara M, Harvey BK, Voutilainen MH, Shen H, Chou J, et al.

Pain in Parkinson's disease

Author(s): Ha AD, Jankovic J

Pain sensitivity and clinical progression in Parkinson's disease

Author(s): Mylius V, Brebbermann J, Dohmann H, Engau I, Oertel WH, et al.

Validation of the non-motor symptoms questionnaire (NMS-Quest)

Author(s): Romenets SR, Wolfson C, Galatas C, Pelletier A, Altman R, et al.