Change in central kinin B2 receptor density after exercise training in rats

Author(s): Caetano AL, Viel TA, Bittencourt MF, Araujo MS, De Angelis K, et al.


Cardiovascular responses elicited by the stimulation of kinin B2 receptors in the IV cerebral ventricle, paratrigeminal nucleus or in the thoracic spinal cord are similar to those observed during an exercise bout. Considering that the kalikrein-kinin system (KKS) could act on the cardiovascular modulation during behavioral responses as physical exercise or stress, this study evaluated the central B2 receptor densities of Wistar (W) and spontaneously hypertensive rats (SHR) after chronic moderate exercise. Animals were exercise-trained for ten weeks on a treadmill. Afterwards, systolic blood pressure decreased in both trained strains. Animals were killed and the medulla and spinal cord extracted for B2 receptor autoradiography. Trained animals were compared to their sedentary controls. Sedentary groups showed specific binding sites for Hoe-140 (fmol/mg of tissue) in laminas 1 and 2 of the spinal cord, nucleus of the solitary tract (NTS), area postrema (AP), spinal trigeminal tract (sp5) and paratrigeminal nucleus (Pa5). In trained W a significant increase (p<0.05) in specific binding was observed in the Pa5 (31.3%) and NTS (28.2%). Trained SHR showed a significant decrease in receptor density in lamina 2 (21.9%) of the thoracic spinal cord and an increase in specific binding in Pa5 (36.1%). We suggest that in the medulla, chronic exercise could hyper stimulate the KKS enhancing their efficiency through the increase of B2 receptor density, involving this receptor in central cardiovascular control during exercise or stress. In the lamina 2, B2 receptor might be involved in the exercise-induced hypotension.

Similar Articles

Global recommendations on physical activity for health

Author(s): World Health Organization (WHO)

Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice

Author(s): Young JW, Crawford N, Kelly JS, Kerr LE, Marston HM, et al.

Therapeutic action of physical exercise on markers of oxidative stress induced by chronic kidney disease

Author(s): de Souza PS, da Rocha LG, Tromm CB, Scheffer DL, Victor EG, et al.

Increases of kinin B1 and B2 receptors binding sites after brain infusion of amyloid-beta 1-40 peptide in rats

Author(s): Viel TA, Caetano AL, Nasello AG, Lancelotti CL, Nunes VA, et al.

Free radicals and oxidative stress in exercise--immunological aspects

Author(s): Niess AM, Dickhuth HH, Northoff H, Fehrenbach E

Exercise, free radicals and oxidative stress

Author(s): Cooper CE, Vollaard NB, Choueiri T, Wilson MT

Intensity-controlled treadmill running in rats: VO(2 max) and cardiac hypertrophy

Author(s): Wisløff U, Helgerud J, Kemi OJ, Ellingsen O

Molecular pharmacological dissection of short- and long-term memory

Author(s): Izquierdo LA, Barros DM, Vianna MR, Coitinho A, deDavid e Silva T, et al.

Treadmill Running Reverses Cognitive Declines due to Alzheimer Disease

Author(s): Cho J, Shin MK, Kim D, Lee I, Kim S, et al.

Inhibitory Plasticity Balances Excitation and Inhibition in Sensory Pathways and Memory Networks

Author(s): Vogels TP, Sprekeler H, Zenke F, Clopath C, Gerstner W