Haptoglobin alters oxygenation and oxidation of hemoglobin and decreases propagation of peroxide-induced oxidative reactions

Author(s): Banerjee S, Jia Y, Siburt CJ, Abraham B, Wood F, et al.


Heme oxygenase-1, an enzyme degrading heme to carbon monoxide, iron, and biliverdin, has been recognized as playing a crucial role in cellular defense against stressful conditions, not only related to heme release. HO-1 protects endothelial cells from apoptosis, is involved in blood-vessel relaxation regulating vascular tone, attenuates inflammatory response in the vessel wall, and participates in blood-vessel formation by means of angiogenesis and vasculogenesis. The latter functions link HO-1 not only to cardiovascular ischemia but also to many other conditions that, like development, wound healing, or cancer, are dependent on neovascularization. The aim of this comprehensive review is to address the mechanisms of HO-1 regulation and function in cardiovascular physiology and pathology and to demonstrate some possible applications of the vast knowledge generated so far. Recent data provide powerful evidence for the involvement of HO-1 in the therapeutic effect of drugs used in cardiovascular diseases. Novel studies open the possibilities of application of HO-1 for gene and cell therapy. Therefore, research in forthcoming years should help to elucidate both the real role of HO-1 in the effect of drugs and the clinical feasibility of HO-1–based cell and gene therapy, creating the effective therapeutic avenues for this refined antioxidant system.

Similar Articles

Contribution of PGE2 EP1 receptor in hemin-induced neurotoxicity

Author(s): Mohan S, Glushakov AV, Decurnou A, Narumiya S, Dore S

Heme oxygenase-1 and the vascular bed: from molecular mechanisms to therapeutic opportunities

Author(s): Loboda A, Jazwa A, Grochot-Przeczek A, Rutkowski AJ, Cisowski J, et al.

mu-Opioid receptor attenuates Abeta oligomers-induced neurotoxicity through mTOR signaling

Author(s): Wang Y, Wang YX, Liu T, Law PY, Loh HH, et al.

Morphine protects for head trauma induced cognitive deficits in mice

Author(s): Zohar O, Getslev V, Miller AL, Schreiber S, Pick CG

Morphine modulation of the ubiquitin-proteasome complex is neuroprotective

Author(s): Rambhia S, Mantione KJ, Stefano GB, Cadet P

International Union of Pharmacology

Author(s): Dhawan BN, Cesselin F, Raghubir R, Reisine T, Bradley PB, et al.

Opiate receptor binding affected differentially by opiates and opioid peptides

Author(s): Childers SR, Creese I, Snowman AM, Synder SH

The role of opioid receptors in hypoxic preconditioning against seizures in brain

Author(s): Rubaj A, Gustaw K, ZgodziƄski W, Kleinrok Z, Sieklucka-Dziuba M