Author(s): Vogels TP, Sprekeler H, Zenke F, Clopath C, Gerstner W
Cortical neurons receive balanced excitatory and inhibitory synaptic currents. Such a balance could be established and maintained in an experience-dependent manner by synaptic plasticity at inhibitory synapses. We show that this mechanism provides an explanation for the sparse firing patterns observed in response to natural stimuli and fits well with a recently observed interaction of excitatory and inhibitory receptive field plasticity. The introduction of inhibitory plasticity in suitable recurrent networks provides a homeostatic mechanism that leads to asynchronous irregular network states. Further, it can accommodate synaptic memories with activity patterns that become indiscernible from the background state but can be reactivated by external stimuli. Our results suggest an essential role of inhibitory plasticity in the formation and maintenance of functional cortical circuitry.
Referred From: https://www.science.org/doi/abs/10.1126/science.1211095
Author(s): World Health Organization (WHO)
Author(s): Batty GD
Author(s): Huang YY, Kandel ER, Levine A
Author(s): Ondrejcak T, Wang Q, Kew JN, Virley DJ, Upton N, et al.
Author(s): Mielke JG, Mealing GA
Author(s): Boccia MM, Blake MG, Krawczyk MC, Baratti CM
Author(s): Young JW, Crawford N, Kelly JS, Kerr LE, Marston HM, et al.
Author(s): Rezvani AH, Kholdebarin E, Brucato FH, Callahan PM, Lowe DA, et al.
Author(s): Viel TA, Caetano AL, Albuquerque MS, Araujo MS, Buck HS, et al.
Author(s): Brown BM, Peiffer JJ, Martins RN
Author(s): Staples MC, Somkuwar SS, Mandyam CD
Author(s): Li H, Liang A, Guan F, Fan R, Chi L, et al.
Author(s): Zhou X, Nai Q, Chen M, Dittus JD, Howard MJ, et al.
Author(s): Massey KA, Zago WM, Berg DK
Author(s): Brinkmann C, Brixius K
Author(s): Cardoso AM, Bagatini MD, Roth MA, Martins CC, Rezer JF, et al.
Author(s): de Souza PS, da Rocha LG, Tromm CB, Scheffer DL, Victor EG, et al.
Author(s): Viel TA, Caetano AL, Nasello AG, Lancelotti CL, Nunes VA, et al.
Author(s): Rodrigues B, Figueroa DM, Mostarda CT, Heeren MV, Irigoyen MC, et al.
Author(s): Caetano AL, Viel TA, Bittencourt MF, Araujo MS, De Angelis K, et al.
Author(s): Pfeffer JM, Pfeffer MA, Frohlich ED
Author(s): Baraldi T, Schöwe NM, Balthazar J, Monteiro-Silva KC, Albuquerque MS, et al.
Author(s): Davies AR, Hardick DJ, Blagbrough IS, Potter BV, Wolstenholme AJ, et al.
Author(s): Behrman S, Ebmeier KP
Author(s): Vella SA, Cliff DP, Magee CA, Okely AD
Author(s): Niess AM, Dickhuth HH, Northoff H, Fehrenbach E
Author(s): Cooper CE, Vollaard NB, Choueiri T, Wilson MT
Author(s): Wisløff U, Helgerud J, Kemi OJ, Ellingsen O
Author(s): Izquierdo LA, Barros DM, Vianna MR, Coitinho A, deDavid e Silva T, et al.
Author(s): Sears RM, Schiff HC, LeDoux JE
Author(s): Koo JH, Kwon IS, Kang EB, Lee CK, Lee NH, et al.
Author(s): Cho J, Shin MK, Kim D, Lee I, Kim S, et al.
Author(s): Zoladz JA, Pilc A
Author(s): Singh AM, Staines WR
Author(s): Kawai H, Zago W, Berg DK
Author(s): Kroker KS, Moreth J, Kussmaul L, Rast G, Rosenbrock H