Author(s): Li H, Liang A, Guan F, Fan R, Chi L, et al.
A substantial amount of evidence has shown that treadmill running enhances neurogenesis, improves cognitive function, and protects the brain against neurodegenerative disorders. However, treadmill running is a type of forced exercise that could increase the level of corticosterone, which subsequently down-regulates neurogenesis and impairs cognitive function. The purpose of this study was to investigate if regular treadmill running provides a balance between the positive and negative effects of treadmill running. The mice were divided into four groups: controls (CON), regular runners (RR), irregular duration runners (IDR) and irregular time-of-day runners (ITR). The RR mice ran daily on the treadmill at the same time-of-day, speed and duration. The IDR mice ran at the same time-of-day and speed, but for a different duration. The ITR mice ran at the same speed and duration, but at different time-of-day. The results showed that regular treadmill running could increase neurogenesis and improve spatial learning and memory performance, as well as decrease the level of corticosterone. The present finding emphasizes the importance of regular physical exercise on cognition.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/23916669
Author(s): World Health Organization (WHO)
Author(s): Batty GD
Author(s): Huang YY, Kandel ER, Levine A
Author(s): Ondrejcak T, Wang Q, Kew JN, Virley DJ, Upton N, et al.
Author(s): Mielke JG, Mealing GA
Author(s): Boccia MM, Blake MG, Krawczyk MC, Baratti CM
Author(s): Young JW, Crawford N, Kelly JS, Kerr LE, Marston HM, et al.
Author(s): Rezvani AH, Kholdebarin E, Brucato FH, Callahan PM, Lowe DA, et al.
Author(s): Viel TA, Caetano AL, Albuquerque MS, Araujo MS, Buck HS, et al.
Author(s): Brown BM, Peiffer JJ, Martins RN
Author(s): Staples MC, Somkuwar SS, Mandyam CD
Author(s): Zhou X, Nai Q, Chen M, Dittus JD, Howard MJ, et al.
Author(s): Massey KA, Zago WM, Berg DK
Author(s): Brinkmann C, Brixius K
Author(s): Cardoso AM, Bagatini MD, Roth MA, Martins CC, Rezer JF, et al.
Author(s): de Souza PS, da Rocha LG, Tromm CB, Scheffer DL, Victor EG, et al.
Author(s): Viel TA, Caetano AL, Nasello AG, Lancelotti CL, Nunes VA, et al.
Author(s): Rodrigues B, Figueroa DM, Mostarda CT, Heeren MV, Irigoyen MC, et al.
Author(s): Caetano AL, Viel TA, Bittencourt MF, Araujo MS, De Angelis K, et al.
Author(s): Pfeffer JM, Pfeffer MA, Frohlich ED
Author(s): Baraldi T, Schöwe NM, Balthazar J, Monteiro-Silva KC, Albuquerque MS, et al.
Author(s): Davies AR, Hardick DJ, Blagbrough IS, Potter BV, Wolstenholme AJ, et al.
Author(s): Behrman S, Ebmeier KP
Author(s): Vella SA, Cliff DP, Magee CA, Okely AD
Author(s): Niess AM, Dickhuth HH, Northoff H, Fehrenbach E
Author(s): Cooper CE, Vollaard NB, Choueiri T, Wilson MT
Author(s): Wisløff U, Helgerud J, Kemi OJ, Ellingsen O
Author(s): Izquierdo LA, Barros DM, Vianna MR, Coitinho A, deDavid e Silva T, et al.
Author(s): Sears RM, Schiff HC, LeDoux JE
Author(s): Koo JH, Kwon IS, Kang EB, Lee CK, Lee NH, et al.
Author(s): Cho J, Shin MK, Kim D, Lee I, Kim S, et al.
Author(s): Zoladz JA, Pilc A
Author(s): Singh AM, Staines WR
Author(s): Kawai H, Zago W, Berg DK
Author(s): Kroker KS, Moreth J, Kussmaul L, Rast G, Rosenbrock H
Author(s): Vogels TP, Sprekeler H, Zenke F, Clopath C, Gerstner W