Related Subjects

A computational model of the digestive gland epithelial cell of mmarine mussels and its simulated responses to oil-derived aromatic hydrocarbons

Author(s): Moore MN, Allen JI


This paper describes a computational model of digestive gland epithelial cells (digestive cells) of marine mussels. These cells are the major environmental interface for uptake of contaminants, particularly those associated with natural particulates that are filtered from seawater by mussels. Digestive cells show well characterised reactions to exposure to lipophilic xenobiotics, such as oil-derived aromatic hydrocarbons (AHs), which accumulate in these cells with minimal biotransformation. The simulation model is based on processes associated with the flux of carbon through the cell. Physiological parameters such as fluctuating food concentration, cell volume, respiration, secretion/excretion, storage of glycogen and lipid, protein/organelle turnover (autophagy/resynthesis) and export of carbon to other tissues of the mussel are all included in the model. The major response to AHs is induction of increased autophagy in these cells. Simulations indicate that the reactions to AHs and food deprivation correspond well with responses measured in vivo.

Similar Articles

Molluscs in biological monitoring of water quality

Author(s): Salánki J, Farkas A, Kamardina T, Rózsa KS

Metal Contamination in Aquatic Environments

Author(s): Luoma SN, Rainbow PS

Molluscs as multidisciplinary models in environmental toxicology

Author(s): Rittschof D, McClellan-Green P

Response of Mytilus galloprovincialis (L

Author(s): Anestis A, Pörtner HO, Karagiannis D, Angelidis P, Staikou A, et al.

Integrated use of biomarkers (superoxide dismutase, catalase and lipid peroxidation)

Author(s): Vlahogianni TM, Dassenakis M, Scoullos J, Valavanidis A

Monitoring the biochemical and cellular responses of marine bivalves during thermal stress by using biomarkers

Author(s): Dimitriadis VK, Gougoula C, Anestis A, Pörtner HO, Michaelidis B

Biomarker responses of mussels exposed to earthquake disturbances

Author(s): Chandurvelan R, Marsden ID, Glover CN, Gaw S

Aquat Toxicol 142-143: 283-293

Author(s): Chandurvelan R, Marsden ID, Gaw S, Glover CN (2013 b) Waterborne cadmium impacts immunocytotoxic and cytogenotoxic endpoints in green-lipped mussel, Perna canaliculus

Metals, toxicity and oxidative stress

Author(s): Valko M, Morris H, Cronin MTD

Spatial and temporary trends on contaminants in mussel sampled around the Icelandic coastline

Author(s): Sturludottir E, Gunnlaugsdottir H, Jorundsdottir HO, Magnusdottir EV, Olafsdottir K, et al.

Glutathione peroxidase and catalase modulate the genotoxicity of arsenic

Author(s): Wang TS, Shu YF, Liu YC, Jan KY, Huang H

Heavy metals and glutathione metabolism in mussel tissues

Author(s): Canesi L, Viarengo A, Leonzio C, Filippelli M, Gallo G