Recommended Conferences

International Conference on Climate Change Global Warming

Berlin, Germany
Related Subjects

Subcellular partitioning and the prediction of cadmium toxicity to aquatic organisms

Author(s): Wang WX, Rainbow PS


The internal metal sequestration strategies of different aquatic organisms are complex and variable; thus it is a formidable task to predict metal toxicity. Metals accumulated by aquatic organisms are associated with different subcellular compartments (i.e. heat-sensitive proteins, heat-stable proteins (metallothioneins), granules, cellular debris, and organelles). Such subcellular partitioning is dynamic in response to metal exposure and other environmental conditions, and is metal- and organism-specific. Previous models predicting metal toxicity have relied on the free ion metal activity (i.e. the free ion activity model) or more recently on the metal binding with the proposed toxicological site of action (i.e. the biotic ligand model). Neither of these models considers the complexity of internal metal subcellular fractionation, which may significantly affect metal toxicity in aquatic organisms and subsequent trophic transfer of metals to consumers. Recent studies in small aquatic organisms have revealed that the subcellular partitioning model (SPM) may provide an improved method to predict Cd toxicity, but more studies are needed in the future.

Similar Articles

Molluscs in biological monitoring of water quality

Author(s): Salánki J, Farkas A, Kamardina T, Rózsa KS

Metal Contamination in Aquatic Environments

Author(s): Luoma SN, Rainbow PS

Molluscs as multidisciplinary models in environmental toxicology

Author(s): Rittschof D, McClellan-Green P

Response of Mytilus galloprovincialis (L

Author(s): Anestis A, Pörtner HO, Karagiannis D, Angelidis P, Staikou A, et al.

Integrated use of biomarkers (superoxide dismutase, catalase and lipid peroxidation)

Author(s): Vlahogianni TM, Dassenakis M, Scoullos J, Valavanidis A

Monitoring the biochemical and cellular responses of marine bivalves during thermal stress by using biomarkers

Author(s): Dimitriadis VK, Gougoula C, Anestis A, Pörtner HO, Michaelidis B

Biomarker responses of mussels exposed to earthquake disturbances

Author(s): Chandurvelan R, Marsden ID, Glover CN, Gaw S

Aquat Toxicol 142-143: 283-293

Author(s): Chandurvelan R, Marsden ID, Gaw S, Glover CN (2013 b) Waterborne cadmium impacts immunocytotoxic and cytogenotoxic endpoints in green-lipped mussel, Perna canaliculus

Metals, toxicity and oxidative stress

Author(s): Valko M, Morris H, Cronin MTD

Spatial and temporary trends on contaminants in mussel sampled around the Icelandic coastline

Author(s): Sturludottir E, Gunnlaugsdottir H, Jorundsdottir HO, Magnusdottir EV, Olafsdottir K, et al.

Glutathione peroxidase and catalase modulate the genotoxicity of arsenic

Author(s): Wang TS, Shu YF, Liu YC, Jan KY, Huang H

Heavy metals and glutathione metabolism in mussel tissues

Author(s): Canesi L, Viarengo A, Leonzio C, Filippelli M, Gallo G