Recommended Conferences

Neuroscience Psychiatry

Dubai, UAE

2nd International Conference on Clinical Psychiatry

Miami, USA

Psychology and Mental Health

Chicago, USA
Related Subjects
 

A co twin-control analysis of drug use and abuse/dependence risk associated with early-onset cannabis use

Author(s): Grant JD, Lynskey MT, Scherrer JF, Agrawal A, Heath AC, et al.

Abstract

We assessed whether, after controlling for genetic and shared environmental influences, early cannabis use remains a significant predictor of other drug use, abuse, and dependence, and whether the risk for early-users is greater than that for later cannabis users. Data from a 1992 telephone diagnostic interview of 8169 male twins (M = 42.0 years at interview) who served in the U.S. military during the Vietnam-era were used to identify a subsample of 293 monozygotic (MZ) and dizygotic (DZ) twin pairs discordant for early cannabis use (before age 18). Using cotwin-control analyses, outcomes assessed were: lifetime illegal drug use (stimulant/cocaine, sedative, opiate, and hallucinogen/PCP), lifetime DSM-III-R illegal drug abuse/dependence, and lifetime DSM-III-R alcohol dependence. After controlling for covariates, early cannabis users were at greater risk than their later/never-using cotwins for 8 of 9 substance-related comparisons, including: using other illegal drugs (ORs: 2.71–4.09), having illegal drug abuse/dependence (ORs: 2.02–2.13), and developing alcohol dependence (OR = 2.36). When analyses were limited to pairs in which the cotwin used cannabis later, early and later-users only differed significantly on sedative, opiate, and hallucinogen use. After familial influences on early cannabis use were controlled for, cannabis use—regardless of the age of initiation—still conferred increased risk of other illegal drug use, drug abuse/dependence, and alcohol dependence. In contrast to previous research, there is limited evidence for increased risk associated with early-onset use in this sample of Vietnam-era veterans.

Similar Articles

A role for cannabinoid CB1 receptors in mood and anxiety disorders

Author(s): Witkin JM, Tzavara ET, Nomikos GG

Adverse health effects of non-medical cannabis use

Author(s): Hall W, Degenhardt L

Parietal lobe volume deficits in adolescents with schizophrenia and adolescents with cannabis use disorders

Author(s): Kumra S, Robinson P, Tambyraja R, Jensen D, Schimunek C, et al.

Daily use, especially of high-potency cannabis, drives the earlier onset of psychosis in cannabis users

Author(s): Di Forti M, Sallis H, Allegri F, Trotta A, Ferraro L, et al.

Prevalence and intensity of basic symptoms among cannabis users: An observational study

Author(s): Martinotti G, Di Iorio G, Tedeschi D, De Berardis D, Niolu C, et al.

Rates of psychiatric comorbidity among U

Author(s): Agosti V, Nunes E, Levin F

Cannabis use and depression: a longitudinal study of a national cohort of Swedish conscripts

Author(s): Manrique-Garcia E, Zammit S, Dalman C, Hemmingsson T, Allebeck P

Escalation of drug use in early-onset cannabis users vs

Author(s): Lynskey MT, Heath AC, Bucholz KK, Slutske WS, Madden PA, et al.

Cannabis use and risk of psychotic or affective mental health outcomes: A systematic review

Author(s): Moore THN, Zammit S, Lingford-Hughes A, Barnes TRE, Jones PB

Genetic predisposition to schizophrenia associated with increased use of cannabis

Author(s): Power RA, Verweij KJH, Zuhair M, Montgomery GW, Henders AK, et al.

The association between cannabis use and depression: A systematic review and meta-analysis of longitudinal studies

Author(s): Lev-Ran S, Roerecke M, Le Foll B, George TP, McKenzie K, et al.

Major depression: The relative contribution of gender, MDMA and cannabis use

Author(s): Durdle H, Lundahl LH, Johanson CE, Tancer M

Relief-oriented use of marijuana by teens

Author(s): Bottorff JL1, Johnson JL, Moffat BM, Mulvogue T

Motives for drug use among light and heavy users

Author(s): Nail RL, Gunderson EK, Kolb D

Risk factors predicting changes in marijuana involvement in teenagers

Author(s): Van den Bree, Marianne BM, Wallace BP

Affect dysregulation in cannabis abusers: A study in adolescents and young adults

Author(s): Dorard G, Berthoz S, Phan O, Corcos M, Bungener C

Adolescent depression and risk factors

Author(s): Field T, Diego M, Sanders C

Cannabis, motivation and life satisfaction in an internet sample

Author(s): Barnwell SS, Earleywine M, Wilcox R

Sequencing of substance use and affective morbidity in 166 first episode bipolar I disorder patients

Author(s): Baethge C, Hennen J, Khalsa HM, Salvatore P, Tohen M, et al.

Adverse health effects of marijuana use

Author(s): Volkow ND, Baler RD, Compton WM, Weiss SR