Author(s): Palacios N, Gao X, McCullough ML
Caffeine consumption has been associated with a reduced risk of Parkinson's disease (PD). The association is strong and consistent in men, but uncertain in women, possibly because of an interaction with hormone replacement therapy (HRT). We sought to confirm these findings using data on PD incidence in the Cancer Prevention Study II Nutrition Cohort (CPS II–Nutrition), a large, prospective study of men and women. We conducted a prospective study of caffeine intake and risk of PD within the CPS II Nutrition Cohort. Intakes of coffee and other sources of caffeine were assessed at baseline. Incident cases of PD (n = 317; 197 men and 120 women) were confirmed by treating physicians and medical record review. Relative risks (RRs) were estimated using proportional hazards models, adjusting for age, smoking, and alcohol consumption. After adjustment for age, smoking, and alcohol intake, high caffeine consumption was associated with a reduced risk of PD. The RR comparing the 5th to the 1st quintile of caffeine intake was 0.43 (95% confidence interval [CI]: 0.26, 0.71; P trend = <0.002) in men, and 0.61 (95% CI: 0.34, 1.09; P trend = 0.05) in women. Among women, this association was stronger among never users of HRT (RR = 0.32) than among ever users (RR = 0.81; P interaction = 0.15). Consumption of decaffeinated coffee was not associated with PD risk. Findings from this large, prospective study of men and women are consistent with a protective effect of caffeine intake on PD incidence, with an attenuating influence of HRT in women.
Referred From: https://onlinelibrary.wiley.com/doi/10.1002/mds.25076
Author(s): Nehlig A, Daval JL, Debry G
Author(s): Majithia N
Author(s): Evans JC
Author(s): Bolton S, Null G
Author(s): Cano-Marquina A, Tarín JJ, Cano A
Author(s): Qi H, Li S
Author(s): Ding M, Bhupathiraju SN, Satija A, van Dam RM, Hu FB
Author(s): Juliano LM, Griffiths RR
Author(s): Robertson D, Wade D, Workman R, Woosley RL, Oateshttp JA
Author(s): Frary CD, Johnson RK, Wang MQ
Author(s): Barone JJ, Roberts HR
Author(s): Winston AP, Hardwick E, Jaberi N
Author(s): Verkhratsky A
Author(s): Holmgren P, Nordén-Pettersson L, Ahlner J
Author(s): Rodopoulos N, Wisén O, Norman A
Author(s): Uddin MS, Wali MW, Mamun AA, Asaduzzaman M, Amran MS, et al.
Author(s): Liguori A, Hughes JR, Grass JA
Author(s): James JE
Author(s): Vanderveen JE, Armstrong LE, Butterfield GE, Chenoweth WL, Dwyer JT, et al.
Author(s): Parsons WD, Neims AH
Author(s): Aranda JV, Cook CE, Gorman W, Collinge JM, Loughnan PM, et al.
Author(s): Aranda JV, Sitar DS, Parsons WD, Loughnan PM, Neims AH
Author(s): Finnegan D
Author(s): Coelho A, Fraichard S, Le Goff G, Faure P, Artur Y, Ferveur JF, Heydel JM
Author(s): Verbeeck RK
Author(s): Borycz J, Pereira MF, Melani A, Rodrigues RJ, Kofalvi A, et al.
Author(s): Baker WJ, Theologus GC
Author(s): Bolton S, Null G
Author(s): Chen JF, Chern Y
Author(s): Camilo O, Goldstein LB
Author(s): Yadav S, Gupta SP, Srivastava G, Srivastava PK, Singh MP
Author(s): Salvemini D, Kim SF, Mollace V
Author(s): Federico S, Spalluto G
Author(s): Chu YF, Chang WH, Black RM, Liu JR, Sompol P, et al.
Author(s): Sonsalla PK, Wong LY, Harris SL
Author(s): Chen X, Ghribi O, Geiger JD
Author(s): Prasanthi JR, Dasari B, Marwarha G