Recommended Conferences

Neuroscience Psychiatry

Dubai, UAE

2nd International Conference on Clinical Psychiatry

Miami, USA

Psychology and Mental Health

Chicago, USA
Related Subjects
 

Delayed caffeine treatment prevents nigral dopamine neuron loss in a progressive rat model of Parkinson's disease

Author(s): Sonsalla PK, Wong LY, Harris SL

Abstract

Parkinson's disease (PD) is characterized by a prominent degeneration of nigrostriatal dopamine (DA) neurons with an accompanying neuroinflammation. Despite clinical and preclinical studies of neuroprotective strategies for PD, there is no effective treatment for preventing or slowing the progression of neurodegeneration. The inverse correlation between caffeine consumption and risk of PD suggests that caffeine may exert neuroprotection. Whether caffeine is neuroprotective in a chronic progressive model of PD has not been evaluated nor is it known if delayed caffeine treatment can stop DA neuronal loss. We show that a chronic unilateral intra-cerebroventricular infusion of 1-methyl-4-phenylpyridinium in the rat brain for 28 days produces a progressive loss of DA and tyrosine hydroxylase in the ipsilateral striatum and a loss of DA cell bodies and microglial activation in the ipsilateral substantia nigra. Chronic caffeine consumption prevented the degeneration of DA cell bodies in the substantia nigra. Importantly, neuroprotection was still apparent when caffeine was introduced after the onset of the neurodegenerative process. These results add to the clinical relevance for adenosine receptors as a disease-modifying drug target for PD.

Similar Articles

The impact of coffee on health

Author(s): Cano-Marquina A, Tarín JJ, Cano A

Tolerance to the humoral and hemodynamic effects of caffeine in man

Author(s): Robertson D, Wade D, Workman R, Woosley RL, Oateshttp JA

Caffeine consumption

Author(s): Barone JJ, Roberts HR

Neuropsychiatric effects of caffeine

Author(s): Winston AP, Hardwick E, Jaberi N

Caffeine fatalities – four case reports

Author(s): Holmgren P, Nordén-Pettersson L, Ahlner J

Caffeine metabolism in patients with chronic liver disease

Author(s): Rodopoulos N, Wisén O, Norman A

Assessment of risk involved in the combination medicine of paracetamol and caffeine

Author(s): Uddin MS, Wali MW, Mamun AA, Asaduzzaman M, Amran MS, et al.

Caffeine for the sustainment of mental task performance: Formulations for military operations

Author(s): Vanderveen JE, Armstrong LE, Butterfield GE, Chenoweth WL, Dwyer JT, et al.

Effect of smoking on caffeine clearance

Author(s): Parsons WD, Neims AH

Pharmacokinetic profile of caffeine in the premature newborn infant with apnea

Author(s): Aranda JV, Cook CE, Gorman W, Collinge JM, Loughnan PM, et al.

Pharmacokinetic aspects of theophylline in premature newborns

Author(s): Aranda JV, Sitar DS, Parsons WD, Loughnan PM, Neims AH

Cytochrome P450-dependent metabolism of caffeine in Drosophila melanogaster

Author(s): Coelho A, Fraichard S, Le Goff G, Faure P, Artur Y, Ferveur JF, Heydel JM

Effects of caffeine on visual monitoring

Author(s): Baker WJ, Theologus GC

Seizures and epilepsy after ischemic stroke

Author(s): Camilo O, Goldstein LB

Crude caffeine reduces memory impairment and amyloid ß(1-42) levels in an Alzheimer's mouse model

Author(s): Chu YF, Chang WH, Black RM, Liu JR, Sompol P, et al.