Author(s): Sonsalla PK, Wong LY, Harris SL
Parkinson's disease (PD) is characterized by a prominent degeneration of nigrostriatal dopamine (DA) neurons with an accompanying neuroinflammation. Despite clinical and preclinical studies of neuroprotective strategies for PD, there is no effective treatment for preventing or slowing the progression of neurodegeneration. The inverse correlation between caffeine consumption and risk of PD suggests that caffeine may exert neuroprotection. Whether caffeine is neuroprotective in a chronic progressive model of PD has not been evaluated nor is it known if delayed caffeine treatment can stop DA neuronal loss. We show that a chronic unilateral intra-cerebroventricular infusion of 1-methyl-4-phenylpyridinium in the rat brain for 28 days produces a progressive loss of DA and tyrosine hydroxylase in the ipsilateral striatum and a loss of DA cell bodies and microglial activation in the ipsilateral substantia nigra. Chronic caffeine consumption prevented the degeneration of DA cell bodies in the substantia nigra. Importantly, neuroprotection was still apparent when caffeine was introduced after the onset of the neurodegenerative process. These results add to the clinical relevance for adenosine receptors as a disease-modifying drug target for PD.
Author(s): Nehlig A, Daval JL, Debry G
Author(s): Majithia N
Author(s): Evans JC
Author(s): Bolton S, Null G
Author(s): Cano-Marquina A, Tarín JJ, Cano A
Author(s): Qi H, Li S
Author(s): Ding M, Bhupathiraju SN, Satija A, van Dam RM, Hu FB
Author(s): Juliano LM, Griffiths RR
Author(s): Robertson D, Wade D, Workman R, Woosley RL, Oateshttp JA
Author(s): Frary CD, Johnson RK, Wang MQ
Author(s): Barone JJ, Roberts HR
Author(s): Winston AP, Hardwick E, Jaberi N
Author(s): Verkhratsky A
Author(s): Holmgren P, Nordén-Pettersson L, Ahlner J
Author(s): Rodopoulos N, Wisén O, Norman A
Author(s): Uddin MS, Wali MW, Mamun AA, Asaduzzaman M, Amran MS, et al.
Author(s): Liguori A, Hughes JR, Grass JA
Author(s): James JE
Author(s): Vanderveen JE, Armstrong LE, Butterfield GE, Chenoweth WL, Dwyer JT, et al.
Author(s): Parsons WD, Neims AH
Author(s): Aranda JV, Cook CE, Gorman W, Collinge JM, Loughnan PM, et al.
Author(s): Aranda JV, Sitar DS, Parsons WD, Loughnan PM, Neims AH
Author(s): Finnegan D
Author(s): Coelho A, Fraichard S, Le Goff G, Faure P, Artur Y, Ferveur JF, Heydel JM
Author(s): Verbeeck RK
Author(s): Borycz J, Pereira MF, Melani A, Rodrigues RJ, Kofalvi A, et al.
Author(s): Baker WJ, Theologus GC
Author(s): Bolton S, Null G
Author(s): Chen JF, Chern Y
Author(s): Camilo O, Goldstein LB
Author(s): Yadav S, Gupta SP, Srivastava G, Srivastava PK, Singh MP
Author(s): Salvemini D, Kim SF, Mollace V
Author(s): Federico S, Spalluto G
Author(s): Chu YF, Chang WH, Black RM, Liu JR, Sompol P, et al.
Author(s): Palacios N, Gao X, McCullough ML
Author(s): Chen X, Ghribi O, Geiger JD
Author(s): Prasanthi JR, Dasari B, Marwarha G