Recommended Conferences

Psychology and Mental Health

Chicago, USA
Related Subjects
 

Genetic predisposition to schizophrenia associated with increased use of cannabis

Author(s): Power RA, Verweij KJH, Zuhair M, Montgomery GW, Henders AK, et al.

Abstract

Cannabis is the most commonly used illicit drug worldwide. With debate surrounding the legalization and control of use, investigating its health risks has become a pressing area of research. One established association is that between cannabis use and schizophrenia, a debilitating psychiatric disorder affecting ~1% of the population over their lifetime. Although considerable evidence implicates cannabis use as a component cause of schizophrenia, it remains unclear whether this is entirely due to cannabis directly raising risk of psychosis, or whether the same genes that increases psychosis risk may also increase risk of cannabis use. In a sample of 2082 healthy individuals, we show an association between an individual’s burden of schizophrenia risk alleles and use of cannabis. This was significant both for comparing those who have ever versus never used cannabis (P=2.6 × 10−4), and for quantity of use within users (P=3.0 × 10−3). Although directly predicting only a small amount of the variance in cannabis use, these findings suggest that part of the association between schizophrenia and cannabis is due to a shared genetic aetiology. This form of gene–environment correlation is an important consideration when calculating the impact of environmental risk factors, including cannabis use.

Similar Articles

A role for cannabinoid CB1 receptors in mood and anxiety disorders

Author(s): Witkin JM, Tzavara ET, Nomikos GG

Adverse health effects of non-medical cannabis use

Author(s): Hall W, Degenhardt L

Parietal lobe volume deficits in adolescents with schizophrenia and adolescents with cannabis use disorders

Author(s): Kumra S, Robinson P, Tambyraja R, Jensen D, Schimunek C, et al.

Daily use, especially of high-potency cannabis, drives the earlier onset of psychosis in cannabis users

Author(s): Di Forti M, Sallis H, Allegri F, Trotta A, Ferraro L, et al.

Prevalence and intensity of basic symptoms among cannabis users: An observational study

Author(s): Martinotti G, Di Iorio G, Tedeschi D, De Berardis D, Niolu C, et al.

Rates of psychiatric comorbidity among U

Author(s): Agosti V, Nunes E, Levin F

Cannabis use and depression: a longitudinal study of a national cohort of Swedish conscripts

Author(s): Manrique-Garcia E, Zammit S, Dalman C, Hemmingsson T, Allebeck P

Escalation of drug use in early-onset cannabis users vs

Author(s): Lynskey MT, Heath AC, Bucholz KK, Slutske WS, Madden PA, et al.

A co twin-control analysis of drug use and abuse/dependence risk associated with early-onset cannabis use

Author(s): Grant JD, Lynskey MT, Scherrer JF, Agrawal A, Heath AC, et al.

Cannabis use and risk of psychotic or affective mental health outcomes: A systematic review

Author(s): Moore THN, Zammit S, Lingford-Hughes A, Barnes TRE, Jones PB

The association between cannabis use and depression: A systematic review and meta-analysis of longitudinal studies

Author(s): Lev-Ran S, Roerecke M, Le Foll B, George TP, McKenzie K, et al.

Major depression: The relative contribution of gender, MDMA and cannabis use

Author(s): Durdle H, Lundahl LH, Johanson CE, Tancer M

Relief-oriented use of marijuana by teens

Author(s): Bottorff JL1, Johnson JL, Moffat BM, Mulvogue T

Motives for drug use among light and heavy users

Author(s): Nail RL, Gunderson EK, Kolb D

Risk factors predicting changes in marijuana involvement in teenagers

Author(s): Van den Bree, Marianne BM, Wallace BP

Affect dysregulation in cannabis abusers: A study in adolescents and young adults

Author(s): Dorard G, Berthoz S, Phan O, Corcos M, Bungener C

Adolescent depression and risk factors

Author(s): Field T, Diego M, Sanders C

Cannabis, motivation and life satisfaction in an internet sample

Author(s): Barnwell SS, Earleywine M, Wilcox R

Sequencing of substance use and affective morbidity in 166 first episode bipolar I disorder patients

Author(s): Baethge C, Hennen J, Khalsa HM, Salvatore P, Tohen M, et al.

Adverse health effects of marijuana use

Author(s): Volkow ND, Baler RD, Compton WM, Weiss SR