Recommended Conferences

2nd International Conference on Clinical Psychiatry

Miami, USA

Neuroscience Psychiatry

Dubai, UAE

Psychology and Mental Health

Chicago, USA
Related Subjects
 

The association between cannabis use and depression: A systematic review and meta-analysis of longitudinal studies

Author(s): Lev-Ran S, Roerecke M, Le Foll B, George TP, McKenzie K, et al.

Abstract

Background

Longitudinal studies reporting the association between cannabis use and developing depression provide mixed results. The objective of this study was to establish the extent to which different patterns of use of cannabis are associated with the development of depression using meta-analysis of longitudinal studies.

Method

Peer-reviewed publications reporting the risk of developing depression in cannabis users were located using searches of EMBASE, Medline, PsychINFO and ISI Web of Science. Only longitudinal studies that controlled for depression at baseline were included. Data on several study characteristics, including measures of cannabis use, measures of depression and control variables, were extracted. Odds ratios (ORs) were extracted by age and length of follow-up.

Results

After screening for 4764 articles, 57 articles were selected for full-text review, of which 14 were included in the quantitative analysis (total number of subjects = 76058). The OR for cannabis users developing depression compared with controls was 1.17 [95% confidence interval (CI) 1.05–1.30]. The OR for heavy cannabis users developing depression was 1.62 (95% CI 1.21–2.16), compared with non-users or light users. Meta-regression revealed no significant differences in effect based on age of subjects and marginal difference in effect based on length of follow-up in the individual studies. There was large heterogeneity in the number and type of control variables in the different studies.

Conclusions

Cannabis use, and particularly heavy cannabis use, may be associated with an increased risk for developing depressive disorders. There is need for further longitudinal exploration of the association between cannabis use and developing depression, particularly taking into account cumulative exposure to cannabis and potentially significant confounding factors.

Similar Articles

A role for cannabinoid CB1 receptors in mood and anxiety disorders

Author(s): Witkin JM, Tzavara ET, Nomikos GG

Adverse health effects of non-medical cannabis use

Author(s): Hall W, Degenhardt L

Parietal lobe volume deficits in adolescents with schizophrenia and adolescents with cannabis use disorders

Author(s): Kumra S, Robinson P, Tambyraja R, Jensen D, Schimunek C, et al.

Daily use, especially of high-potency cannabis, drives the earlier onset of psychosis in cannabis users

Author(s): Di Forti M, Sallis H, Allegri F, Trotta A, Ferraro L, et al.

Prevalence and intensity of basic symptoms among cannabis users: An observational study

Author(s): Martinotti G, Di Iorio G, Tedeschi D, De Berardis D, Niolu C, et al.

Rates of psychiatric comorbidity among U

Author(s): Agosti V, Nunes E, Levin F

Cannabis use and depression: a longitudinal study of a national cohort of Swedish conscripts

Author(s): Manrique-Garcia E, Zammit S, Dalman C, Hemmingsson T, Allebeck P

Escalation of drug use in early-onset cannabis users vs

Author(s): Lynskey MT, Heath AC, Bucholz KK, Slutske WS, Madden PA, et al.

A co twin-control analysis of drug use and abuse/dependence risk associated with early-onset cannabis use

Author(s): Grant JD, Lynskey MT, Scherrer JF, Agrawal A, Heath AC, et al.

Cannabis use and risk of psychotic or affective mental health outcomes: A systematic review

Author(s): Moore THN, Zammit S, Lingford-Hughes A, Barnes TRE, Jones PB

Genetic predisposition to schizophrenia associated with increased use of cannabis

Author(s): Power RA, Verweij KJH, Zuhair M, Montgomery GW, Henders AK, et al.

Major depression: The relative contribution of gender, MDMA and cannabis use

Author(s): Durdle H, Lundahl LH, Johanson CE, Tancer M

Relief-oriented use of marijuana by teens

Author(s): Bottorff JL1, Johnson JL, Moffat BM, Mulvogue T

Motives for drug use among light and heavy users

Author(s): Nail RL, Gunderson EK, Kolb D

Risk factors predicting changes in marijuana involvement in teenagers

Author(s): Van den Bree, Marianne BM, Wallace BP

Affect dysregulation in cannabis abusers: A study in adolescents and young adults

Author(s): Dorard G, Berthoz S, Phan O, Corcos M, Bungener C

Adolescent depression and risk factors

Author(s): Field T, Diego M, Sanders C

Cannabis, motivation and life satisfaction in an internet sample

Author(s): Barnwell SS, Earleywine M, Wilcox R

Sequencing of substance use and affective morbidity in 166 first episode bipolar I disorder patients

Author(s): Baethge C, Hennen J, Khalsa HM, Salvatore P, Tohen M, et al.

Adverse health effects of marijuana use

Author(s): Volkow ND, Baler RD, Compton WM, Weiss SR