Author(s): Jung S, Panchalingam KM, Rosenberg L,Behie LA
Human mesenchymal stem cells (hMSCs) are presently being evaluated for their therapeutic potential in clinical studies to treat various diseases, disorders, and injuries. To date, early-phase studies have indicated that the use of both autologous and allogeneic hMSCs appear to be safe; however, efficacy has not been demonstrated in recent late-stage clinical trials. Optimized cell bioprocessing protocols may enhance the efficacy as well as safety of hMSC therapeutics. Classical media used for generating hMSCs are typically supplemented with ill-defined supplements such as fetal bovine serum (FBS) or human-sourced alternatives. Ideally, culture media are desired to have well-defined serum-free formulations that support the efficient production of hMSCs while maintaining their therapeutic and differentiation capacity. Towards this objective, we review here current cell culture media for hMSCs and discuss medium development strategies.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/22645619
Author(s): Riordan NH, Ichim TE, Min WP, Wang H, Solano F, et al.
Author(s): Faustini M, Bucco M, Chlapanidas T, Lucconi G, Marazzi M, et al.
Author(s): Ho JH, Ma WH, Tseng TC, Chen YF, Chen MH, et al.
Author(s): Neupane M, Chang CC, Kiupel M,Yuzbasiyan-Gurkan V
Author(s): Planat-Benard V, Silvestre JS, Cousin B, Andre M, Nibbelink M, et al.
Author(s): Matsumoto D, Sato K, Gonda K, Takaki Y, Shigeura T, et al.
Author(s): Yoshimura K, Sato K, Aoi N, Kurita M, Hirohi T, et al.
Author(s): Yoshimura K, Sato K, Aoi N, Kurita M, Inoue K, et al.
Author(s): Yoshimura K, Asano Y, Aoi N, Kurita M, Oshima Y, et al.
Author(s): Kim M, Kim I, Lee SK, Bang SI,Lim SY
Author(s): Lendeckel S, Jodicke A, Christophis P, Heidinger K, Wolff J, et al.
Author(s): Gimble JM, Guilak F,Bunnell BA
Author(s): Casteilla L, Planat-Benard V, Laharrague P,Cousin B
Author(s): Griesche N, Luttmann W, Luttmann A, Stammermann T, Geiger H, et al.
Author(s): Zhang S, Espandar L, Imhof KM,Bunnell BA
Author(s): Lin KJ, Loi MX, Lien GS, Cheng CF, Pao HY, et al.
Author(s): Niada S, Ferreira LM, Arrigoni E, Addis A, Campagnol M, et al.
Author(s): Farre-Guasch E, Marti-Page C, Hernadez-Alfaro F, Klein-Nulend J,Casals N
Author(s): Lin K, Matsubara Y, Masuda Y, Togashi K, Ohno T, et al.
Author(s): Spees JL, Gregory CA, Singh H, Tucker HA, Peister A, et al.
Author(s): Sundin M, Ringden O, Sundberg B, Nava S, Gotherstrom C, et al.
Author(s): Santos FD, Andrade PZ, Abecasis MM, Gimble JM, Chase LG, et al.
Author(s): Di Bernardo G, Messina G, Capasso S, Del Gaudio S, Cipollaro M, et al.
Author(s): Perez-Ilzarbe M, Diez-Campelo M, Aranda P, Tabera S, Lopez T, et al.
Author(s): Valencic E, Loganes C, Cesana S, Piscianz E, Gaipa G, et al.
Author(s): Even MS, Sandusky CB,Barnard ND
Author(s): Lindroos B, Boucher S, Chase L, Kuokkanen H, Huhtala H, et al.
Author(s): Felka T, Schafer R, De Zwart P,Aicher WK
Author(s): Hartmann I, Hollweck T, Haffner S, Krebs M, Meiser B, et al.
Author(s): Pal R, Hanwate M, Jan M,Totey S
Author(s): Rajaraman G, White J, Tan KS, Ulrich D, Rosamilia A, et al.
Author(s): Chase LG, Yang S, Zachar V, Yang Z, Lakshmipathy U, et al.
Author(s): Corotchi MC, Popa MA, Remes A, Sima LE, Gussi I, et al.
Author(s): Sun LY, Pang CY, Li DK, Liao CH, Huang WC, et al.
Author(s): Lin PC, Chen YL, Chiu SC, Yu YL, Chen SP, et al.
Author(s): Tsai LP, Lee KF, Fang JS,Liu IY
Author(s): Sun LY, Hsieh DK, Yu TC, Chiu HT, Lu SF, et al.
Author(s): Wang KH, Kao AP, Wangchen H, Wang FY, Chang CH, et al.
Author(s): Honmou O, Houkin K, Matsunaga T, Niitsu Y, Ishiai S, et al.
Author(s): Muller AM, Davenport M, Verrier S, Droeser R, Alini M, et al.
Author(s): Van Pham P, Bui KH, Ngo DQ, Vu NB, Truong NH, et al.
Author(s): Badet L, Benhamou PY, Wojtusciszyn A, Baertschiger R, Milliat-Guittard L, et al.
Author(s): Janssens S, Dubois C, Bogaert J, Theunissen K, Deroose C, et al.
Author(s): De Francesco F, Tirino V, Desiderio V, Ferraro G, D'Andrea F, et al.
Author(s): Traktuev DO, Merfeld-Clauss S, Li J, Kolonin M, Arap W, et al.
Author(s): Lee HJ, Choi BH, Min BH,Park SR
Author(s): Kim WS, Park BS,Sung JH
Author(s): Park BS, Kim WS, Choi JS, Kim HK, Won JH, et al.
