Author(s): Murad S, Grove D, Lindberg KA, Reynolds G, Sivarajah A, et al.
After prolonged exposure to ascorbate, collagen synthesis in cultured human skin fibroblasts increased approximately 8-fold with no significant change in synthesis of noncollagen protein. This effect of ascorbate appears to be unrelated to its cofactor function in collagen hydroxylation. The collagenous protein secreted in the absence of added ascorbate was normal in hydroxylysine but was mildly deficient in hydroxyproline. In parallel experiments, lysine hydroxylase (peptidyllysine, 2-oxoglutarate:oxygen 5-oxidoreductase, EC 1.14.11.4) activity increased 3-fold in response to ascorbate administration whereas proline hydroxylase (prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, EC 1.14.11.2) activity decreased considerably. These results suggest that collage polypeptide synthesis, posttranslational hydroxylations, and activities of the two hydroxylases are independently regulated by ascorbate.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/6265920
Author(s): Wynn TA, Ramalingam TR
Author(s): Sabry MM, Elkalawy SAE, Abo-Elnour RKE, Abd-El-Maksod DF
Author(s): Leung VYL, Aladin DMK, Lv F, Tam V, Sun Y, et al.
Author(s): Qi Y, Jiang D, Sindrilaru A, Stegemann A, Schatz S, et al.
Author(s): Kishore R, Verma SK, Mackie AR, Vaughan EE, Abramova TV, et al.
Author(s): Mias C, Lairez O, Trouche E, Roncalli J, Calise D, et al.
Author(s): Hemphill C, Stavoe K, Khalpey Z
Author(s): Zagoura DS, Roubelakis MG, Bitsika V, Trohatou O, Pappa KI, et al.
Author(s): Zhang DG, Jiang MY, Miao DS
Author(s): Fujimoto KL, Miki T, Liu LJ, Hashizume R, Strom SC, et al.
Author(s): Sedrakyan S, Da Sacco S, Milanesi A, Shiri L, Petrosyan A, et al.
Author(s): Garcia O, Carraro G, Turcatel G, Hall M, Sedrakyan S, et al.
Author(s): Sun D, Bu L, Liu C, Yin Z, Zhou X, et al.
Author(s): Wen ST, Chen W, Chen HL, Lai CW, Yen CC, et al.
Author(s): Baulier E, Favreau F, Le Corf A, Jayle C, Schneider F, et al.
Author(s): Lee WY, Wei HJ, Lin WW, Yeh YC, Hwang SM, et al.
Author(s): Grisafi D, Pozzobon M, Dedja A, Vanzo V, Tomanin R, et al.
Author(s): Moodley Y, Atienza D, Manuelpillai U, Samuel CS, Tchongue J, et al.
Author(s): Cargnoni A, Piccinelli EC, Ressel L, Rossi D, Magatti M, et al.
Author(s): Cargnoni A, Ressel L, Rossi D, Poli A, Arienti D, et al.
Author(s): Wynn TA
Author(s): Klingberg F, Hinz B, White ES
Author(s): Yoon BS, Moon JH, Jun EK, Kim J, Maeng I, et al.
Author(s): Vosdoganes P, Wallace EM, Chan ST, Acharya R, Moss TJM, et al.
Author(s): Hodge A, Lourensz D, Vaghjiani V, Nguyen H, Tchongue J, et al.
Author(s): Jun EK, Zhang Q, Yoon BS, Moon JH, Lee G, et al.
Author(s): Fong CY, Tam K, Cheyyatraivendran S, Gan SU, Gauthaman K, et al.
Author(s): Arno AI, Amini-Nik S, Blit PH, Al-Shebab M, Belo C, et al.
Author(s): Jeon YK, Jang YH, Yoo DR, Kim SN, Lee SK, et al.
Author(s): Kim WS, Park BS, Sung JH, Yang JM, Park SB, et al.
Author(s): Jung H, Kim HH, Lee DH, Hwang YS, Yang HC, et al.
Author(s): Ding J, Ma Z, Shankowsky HA, Medina A, Tredget EE
Author(s): Lee SH, Jin SY, Song JS, Seo KK, Cho KH
Author(s): Onishi S, Sumiyoshi H, Kitamura S, Nagaya N
Author(s): Salazar KD, Lankford SM, Brody AR
Author(s): Cho JW, Kang MC, Lee KS
Author(s): Leung A, Crombleholme TM, Keswani SG
Author(s): Hu MS, Rennert RC, McArdle A, Chung MT, Walmsley GG, et al.
Author(s): Hosper NA, Bank RA, van den Berg PP
Author(s): Przybyt E,Krenning G, Brinker MGL, Harmsen MC
Author(s): Masum MM, Boersema M, Bank RA
Author(s): Skardal A, Mack D, Kapetanovic E, Atala A, Jackson JD, et al.
Author(s): Shi HX, Lin C, Lin BB, Wang ZG, Zhang HY, et al.
Author(s): Kinoshita T, Ishikawa Y, Arita M, Akishima-Fukasawa Y, Fujita K, et al.
Author(s): Desai VD, Hsia HC, Schwatzbauer JE
Author(s): Pinnell SR
Author(s): Tsutsumi K, Fujikawa H, Kaijkawa T, Takedachi M, Yamamoto T, et al.
Author(s): Myllyharju J
Author(s): Ananthanarayanan VS
Author(s): Li Y, Schellhorn HE
Author(s): van der Slot AJ, Zuurmond A, Bardoel AFJ, Wijmenga C, Pruijs HEH, et al.
Author(s): Pornprasertsuk S, Duarte WR, Mochida Y, Yamauchi M
Author(s): van der Slot AJ, van Dura EA, Attema J, Blauw B, DeGroot J, et al.
Author(s): Mast BA, Diegelmann RF, Krummel TM, Cohen IK
Author(s): Longaker MT, Whitby DJ, Ferguson MWJ, Lorenz HP, Harrison MR, et al.
