Author(s): Kondo T, Hayashi M, Takeshita K, Numaguchi Y, Kobayashi K, et al.
Objective: Circulating endothelial progenitor cells (EPCs) contribute to postnatal angiogenesis. The number of circulating EPCs has an inverse correlation with coronary risk scores. However, the effect of smoking on the number of circulating EPCs is not well-known.
Methods and results: We examined the effects of chronic smoking and of smoking cessation on EPC levels. Circulating EPCs were quantified by flow cytometry as CD45lowCD34+CD133+ (progenitor cells [PCs]) or CD45lowCD34+CD133+VEGFR2+ (EPCs) in 14 nonsmokers and in 15 smokers. All smokers quit smoking. Eight quit smoking with nicotine patch and 7 without nicotine patch. PC/EPC levels were inversely correlated with the number of cigarettes smoked. Circulating PCs/EPCs increased rapidly after cessation (P<0.0001) and decreased again after resumption of smoking to the level similar to that before cessation (P=0.0031). The magnitude of increase in EPCs was greater in light smokers than in heavy smokers.
Conclusions: The number of circulating PCs/EPCs was reduced in chronic smokers. Smoking cessation led to a rapid restoration of PC/EPC levels. The recovery of EPC levels was greater in light smokers than in heavy smokers. The decreased number of circulating EPCs would make smokers susceptible to cardiovascular disease, and even short-time cessation of smoking may be an effective means to reduce cardiovascular risk.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/15191940
Author(s): Davenport R, Dennis M
Author(s): Sudlow CL, Warlow CP
Author(s): Fagan SC, Morgenstern LB, Petitta A, Ward RE, Tilley BC, et al.
Author(s): Hess DC, Wang S, Hamilton W, Lee S, Pardue C, et al.
Author(s): Wang S, Gross H, Lee SB, Pardue C, Waller J, et al.
Author(s): Borlongan CV, Fournier C, Stahl CE, Yu G, Xu L, et al.
Author(s): Wang X, Rosell A, Lo EH
Author(s): Switzer JA, Hall C, Gross H, Waller J, Nichols FT, et al.
Author(s): Leira EC, Hess DC, Torner JC, Adams HP Jr
Author(s): Henninger N, Chowdhury N, Fisher M, Moonis M
Author(s): Wu O, Langhorne P
Author(s): Matsukawa N, Yasuhara T, Hara K, Xu L, Maki M, et al.
Author(s): Hill MD, Moy CS, Palesch YY, Martin R, Dillon CR, et al.
Author(s): Toda H, Takahashi J, Iwakami N, Kimura T, Hoki S, et al.
Author(s): Ferrari A, Ehler E, Nitsch RM, Götz J
Author(s): Borlongan CV, Tajima Y, Trojanowski JQ, Lee VMY, Sanberg PR
Author(s): Veizovic T, Beech JS, Stroemer RP, Watson WP, Hodges H
Author(s): Modo M, Stroemer RP, Tang E, Veizovic T, Sowniski P, et al.
Author(s): Englund U, Bjorklund A, Wictorin K, Lindvall O, Kokaia M
Author(s): Kopen GC, Prockop DJ, Phinney DG
Author(s): Chen J, Li Y, Chopp M
Author(s): Li Y, Chopp M, Chen J, Wang L, Gautam SC, et al.
Author(s): Woodbury D, Schwarz EJ, Prockop DJ, Black IB
Author(s): Muñoz-Elias G, Marcus AJ, Coyne TM, Woodbury D, Black IB
Author(s): Borlongan CV, Hadman M, Sanberg CD, Sanberg PR
Author(s): Eglitis MA, Mezey E
Author(s): Li Y, Chen J, Wang L, Lu M, Chopp M
Author(s): Chen J, Sanberg PR, Li Y, Wang L, Lu M, et al.
Author(s): Hess DC, Hill WD, Martin-Studdard A, Carroll J, Brailer J, et al.
Author(s): Willing AE, Lixian J, Milliken M, Poulos S, Zigova T, et al.
Author(s): Chen J, Zhang ZG, Li Y, Wang L, Xu YX, et al.
Author(s): Riess P, Zhang C, Saatman KE, Laurer HL, Longhi LG, et al.
Author(s): Zhao LR, Duan WM, Reyes M, Keene CD, Verfaillie CM, et al.
Author(s): Peled A, Kollet O, Ponomaryov T, Petit I, Franitza S, et al.
Author(s): Yamaguchi J, Kusano KF, Masuo O, Kawamoto A, Silver M, et al.
Author(s): Reyes M, Dudek A, Jahagirdar B, Koodie L, Marker PH, et al.
Author(s): Rajantie I, Ilmonen M, Alminaite A, Ozerdem U, Alitalo K, et al.
Author(s): Mahmood A, Lu D, Chopp M
Author(s): Suárez-Monteagudo C, Hernández-Ramírez P, Alvarez-González L, García-Maeso I, de la Cuétara-Bernal K, et al.
Author(s): Borlongan CV
Author(s): Feuerstein GZ, Zaleska MM, Krams M, Wang X, Day M, et al.
Author(s): Keene CD, Ortiz-Gonzalez XR, Jiang YH, Largaespada DA, Verfaillie CM, et al.
Author(s): Di Nicola M, Carlo-Stella C, Magni M, Milanesi M, Longoni PD, et al.
Author(s): Jorgensen C, Djouad F, Apparailly F, Noël D
Author(s): Le Blanc K, Tammik L, Sundberg B, Haynesworth SE, Ringdén O
Author(s): Aggarwal S, Pittenger MF
Author(s): Tse WT, Pendleton JD, Beyer WM, Egalka MC, Guinan EC
Author(s): Le Blanc K, Rasmusson I, Sundberg B, Götherström C, Hassan M, et al.
Author(s): Reyes M, Verfaillie CM
Author(s): Ayata C, Ropper AH
Author(s): Brouns R, De Deyn PP
Author(s): Aoki T, Sumii T, Mori T, Wang XY, Lo EH
Author(s): Subramaniam S, Hill MD
Author(s): Chang CF, Lin SZ, Chiang YH, Morales M, Chou J, et al.
Author(s): Castillo J, Alvarez-Sabín J, Martínez-Vila E, Montaner J, Sobrino T, et al.
Author(s): Vila N, Castillo J, Dávalos A, Chamorro A
Author(s): Castillo J, Leira R
Author(s): Doyle KP, Simon RP, Stenzel-Poore MP
Author(s): Wang GJ, Deng HY, Maier CM, Sun GH, Yenari MA
Author(s): Tang Y, Xu H, Du X, Lit L, Walker W, et al.
Author(s): Carmeliet P
Author(s): Masuda H, Asahara T
Author(s): Shi Q, Rafii S, Wu MH, Wijelath ES, Yu C, et al.
Author(s): Bompais H, Chagraoui J, Canron X, Crisan M, Liu XH, et al.
Author(s): Pirro M, Schillaci G, Menecali C, Bagaglia F, Paltriccia R, et al.
Author(s): Umemura T, Soga J, Hidaka T, Takemoto H, Nakamura S, et al.
Author(s): Del Papa N, Quirici N, Soligo D, Scavullo C, Cortiana M, et al.
Author(s): Kuwana M, Okazaki Y, Yasuoka H, Kawakami Y, Ikeda Y
Author(s): Heiss C, Keymel S, Niesler U, Ziemann J, Kelm M, et al.
Author(s): Michaud SE, Dussault S, Haddad P, Groleau J, Rivard A
Author(s): Botta R, Gao E, Stassi G, Bonci D, Pelosi E, et al.
Author(s): Kawamoto A, Gwon HC, Iwaguro H, Yamaguchi JI, Uchida S, et al.
Author(s): Madeddu P, Emanueli C, Pelosi E, Salis MB, Cerio AM, et al.
Author(s): Rouhl RP, van Oostenbrugge RJ, Damoiseaux J, Tervaert JW, Lodder J
Author(s): Erbs S, Linke A, Adams V, Lenk K, Thiele H, et al.
Author(s): Li ZQ, Zhang M, Jing YZ, Zhang WW, Liu Y, et al.
Author(s): Meluzín J, Janousek S, Mayer J, Groch L, Hornácek I, et al.
Author(s): Meluzín J, Mayer J, Groch L, Janousek S, Hornácek I, et al.
Author(s): Mocini D, Staibano M, Mele L, Giannantoni P, Menichella G, et al.
Author(s): Perin EC, Dohmann HF, Borojevic R, Silva SA, Sousa AL, et al.
Author(s): Perin EC, Dohmann HF, Borojevic R, Silva SA, Sousa AL, et al.
Author(s): Strauer BE, Brehm M, Zeus T, Bartsch T, Schannwell C, et al.
Author(s): Strauer BE, Brehm M, Zeus T, Köstering M, Hernandez A, et al.
Author(s): Numaguchi Y, Sone T, Okumura K, Ishii M, Morita Y, et al.
Author(s): Döbert N, Britten M, Assmus B, Berner U, Menzel C, et al.
Author(s): Lev EI, Kleiman NS, Birnbaum Y, Harris D, Korbling M, et al.
Author(s): Hristov M, Heussen N, Schober A, Weber C
Author(s): Dimmeler S, Zeiher AM, Schneider MD
Author(s): Higashi Y, Kimura M, Hara K, Noma K, Jitsuiki D, et al.
Author(s): Tateishi-Yuyama E, Matsubara H, Murohara T, Ikeda U, Shintani S, et al.
Author(s): Taguchi A, Matsuyama T, Moriwaki H, Hayashi T, Hayashida K, et al.
Author(s): Ghani U, Shuaib A, Salam A, Nasir A, Shuaib U, et al.
