Author(s): van der Slot AJ, van Dura EA, Attema J, Blauw B, DeGroot J, et al.
Fibrotic processes in humans are characterised by an excessive accumulation of collagen containing increased levels of hydroxyallysine-derived cross-links. The occurrence of these cross-links appears to be an important criterion in assessing the irreversibility of fibrosis. We hypothesise that increased hydroxyallysine cross-linking results in a collagenous matrix that is less susceptible to proteolytic degradation and therefore the collagen deposition is no longer reversible. In this report, we show that collagen matrices with increased hydroxyallysine cross-link levels were less susceptible to matrix metalloproteinase 1 degradation than are collagen matrices containing low hydroxyallysine levels. These data indicate that the type of collagen cross-link influences collagen catabolism. In vivo evidence for the importance of the cross-linking type in determining the reversibility of the fibrotic process was found using the bleomycin-induced skin fibrosis mouse model. The analysis of the accumulated collagen in the fibrotic skin of bleomycin-treated mice did not reveal an increase in hydroxyallysine cross-link levels. In concurrence with our hypothesis, the collagen accumulation resolved in time when the mice were no longer receiving bleomycin treatment, showing the reversibility of the fibrosis. In conclusion, our data indicate that the type of collagen cross-linking is an important factor in determining whether the outcome of the fibrotic process is reversible or not.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/15878742
Author(s): Wynn TA, Ramalingam TR
Author(s): Sabry MM, Elkalawy SAE, Abo-Elnour RKE, Abd-El-Maksod DF
Author(s): Leung VYL, Aladin DMK, Lv F, Tam V, Sun Y, et al.
Author(s): Qi Y, Jiang D, Sindrilaru A, Stegemann A, Schatz S, et al.
Author(s): Kishore R, Verma SK, Mackie AR, Vaughan EE, Abramova TV, et al.
Author(s): Mias C, Lairez O, Trouche E, Roncalli J, Calise D, et al.
Author(s): Hemphill C, Stavoe K, Khalpey Z
Author(s): Zagoura DS, Roubelakis MG, Bitsika V, Trohatou O, Pappa KI, et al.
Author(s): Zhang DG, Jiang MY, Miao DS
Author(s): Fujimoto KL, Miki T, Liu LJ, Hashizume R, Strom SC, et al.
Author(s): Sedrakyan S, Da Sacco S, Milanesi A, Shiri L, Petrosyan A, et al.
Author(s): Garcia O, Carraro G, Turcatel G, Hall M, Sedrakyan S, et al.
Author(s): Sun D, Bu L, Liu C, Yin Z, Zhou X, et al.
Author(s): Wen ST, Chen W, Chen HL, Lai CW, Yen CC, et al.
Author(s): Baulier E, Favreau F, Le Corf A, Jayle C, Schneider F, et al.
Author(s): Lee WY, Wei HJ, Lin WW, Yeh YC, Hwang SM, et al.
Author(s): Grisafi D, Pozzobon M, Dedja A, Vanzo V, Tomanin R, et al.
Author(s): Moodley Y, Atienza D, Manuelpillai U, Samuel CS, Tchongue J, et al.
Author(s): Cargnoni A, Piccinelli EC, Ressel L, Rossi D, Magatti M, et al.
Author(s): Cargnoni A, Ressel L, Rossi D, Poli A, Arienti D, et al.
Author(s): Wynn TA
Author(s): Klingberg F, Hinz B, White ES
Author(s): Yoon BS, Moon JH, Jun EK, Kim J, Maeng I, et al.
Author(s): Vosdoganes P, Wallace EM, Chan ST, Acharya R, Moss TJM, et al.
Author(s): Hodge A, Lourensz D, Vaghjiani V, Nguyen H, Tchongue J, et al.
Author(s): Jun EK, Zhang Q, Yoon BS, Moon JH, Lee G, et al.
Author(s): Fong CY, Tam K, Cheyyatraivendran S, Gan SU, Gauthaman K, et al.
Author(s): Arno AI, Amini-Nik S, Blit PH, Al-Shebab M, Belo C, et al.
Author(s): Jeon YK, Jang YH, Yoo DR, Kim SN, Lee SK, et al.
Author(s): Kim WS, Park BS, Sung JH, Yang JM, Park SB, et al.
Author(s): Jung H, Kim HH, Lee DH, Hwang YS, Yang HC, et al.
Author(s): Ding J, Ma Z, Shankowsky HA, Medina A, Tredget EE
Author(s): Lee SH, Jin SY, Song JS, Seo KK, Cho KH
Author(s): Onishi S, Sumiyoshi H, Kitamura S, Nagaya N
Author(s): Salazar KD, Lankford SM, Brody AR
Author(s): Cho JW, Kang MC, Lee KS
Author(s): Leung A, Crombleholme TM, Keswani SG
Author(s): Hu MS, Rennert RC, McArdle A, Chung MT, Walmsley GG, et al.
Author(s): Hosper NA, Bank RA, van den Berg PP
Author(s): Przybyt E,Krenning G, Brinker MGL, Harmsen MC
Author(s): Masum MM, Boersema M, Bank RA
Author(s): Skardal A, Mack D, Kapetanovic E, Atala A, Jackson JD, et al.
Author(s): Shi HX, Lin C, Lin BB, Wang ZG, Zhang HY, et al.
Author(s): Kinoshita T, Ishikawa Y, Arita M, Akishima-Fukasawa Y, Fujita K, et al.
Author(s): Desai VD, Hsia HC, Schwatzbauer JE
Author(s): Murad S, Grove D, Lindberg KA, Reynolds G, Sivarajah A, et al.
Author(s): Pinnell SR
Author(s): Tsutsumi K, Fujikawa H, Kaijkawa T, Takedachi M, Yamamoto T, et al.
Author(s): Myllyharju J
Author(s): Ananthanarayanan VS
Author(s): Li Y, Schellhorn HE
Author(s): van der Slot AJ, Zuurmond A, Bardoel AFJ, Wijmenga C, Pruijs HEH, et al.
Author(s): Pornprasertsuk S, Duarte WR, Mochida Y, Yamauchi M
Author(s): Mast BA, Diegelmann RF, Krummel TM, Cohen IK
Author(s): Longaker MT, Whitby DJ, Ferguson MWJ, Lorenz HP, Harrison MR, et al.